Search Results
Overview
| Uniprot ID | Q14188 |
|---|---|
| Protein Name | Transcription factor Dp-2 |
| Gene Name | TFDP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | GDRKRARKFIDSDFS |
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812)
Protein Sequence
10
MTAKNVGLTS
20
TNAEVRGFID
30
QNLSPTKGNI
40
SFVAFPVSNT
50
NSPTKILPKT
60
LGPINVNVGP
70
QMIISTPQRL
80
TSSGSVLIGS
90
PYTPAPAMVT
100
QTHIAEATGW
110
VPGDRKRARK
120
FIDSDFSESK
130
RSKKGDKNGK
140
GLRHFSMKVC
150
EKVQRKGTTS
160
YNEVADELVS
170
EFTNSNNHLA
180
ADSAYDQKNI
190
RRRVYDALNV
200
LMAMNIISKE
210
KKEIKWIGLP
220
TNSAQECQNL
230
EIEKQRRIER
240
IKQKRAQLQE
250
LLLQQIAFKN
260
LVQRNRQNEQ
270
QNQGPPALNS
280
TIQLPFIIIN
290
TSRKTVIDCS
300
ISSDKFEYLF
310
NFDNTFEIHD
320
DIEVLKRMGM
330
SFGLESGKCS
340
LEDLKLAKSL
350
VPKALEGYIT
360
DISTGPSWLN
370
QGLLLNSTQS
380
VSNLDLTTGA
390
TLPQSSVNQG
400
LCLDAEVALA
410
TGQFLAPNSH
420
QSSSAASHCS
430
ESRGETPCSF
440
NDEDEEDDEE
DSSSPE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0008134 | transcription factor binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A