Search Results

Overview

Uniprot IDQ14192
Protein NameFour and a half LIM domains protein 2
Gene NameFHL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
17 CNESLFGKKYILREE
253 NDCFNCKKCSLSLVG

Function

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008)

Protein Sequence

10 MTERFDCHHC 20 NESLFGKKYI 30 LREESPYCVV 40 CFETLFANTC 50 EECGKPIGCD 60 CKDLSYKDRH 70 WHEACFHCSQ 80 CRNSLVDKPF 90 AAKEDQLLCT 100 DCYSNEYSSK 110 CQECKKTIMP 120 GTRKMEYKGS 130 SWHETCFICH 140 RCQQPIGTKS 150 FIPKDNQNFC 160 VPCYEKQHAM 170 QCVQCKKPIT 180 TGGVTYREQP 190 WHKECFVCTA 200 CRKQLSGQRF 210 TARDDFAYCL 220 NCFCDLYAKK 230 CAGCTNPISG 240 LGGTKYISFE 250 ERQWHNDCFN 260 CKKCSLSLVG 270 RGFLTERDDI LCPDCGKDI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030018 Z disc
Molecular Function GO:0043425 bHLH transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008134 transcription factor binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0055014 atrial cardiac muscle cell development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060347 heart trabecula formation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0009725 response to hormone
Biological Process GO:0055015 ventricular cardiac muscle cell development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.