Search Results
Overview
| Uniprot ID | Q14194 |
|---|---|
| Protein Name | Dihydropyrimidinase-related protein 1 |
| Gene Name | CRMP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 345 | TAQKAVGKDNFTLIP |
| 426 | TITAKSHKSAVEYNI |
| 463 | DGNINVNKGMGRFIP |
| 472 | MGRFIPRKAFPEHLY |
| 487 | QRVKIRNKVFGLQGV |
| 511 | YEVPATPKYATPAPS |
| 520 | ATPAPSAKSSPSKHQ |
| 525 | SAKSSPSKHQPPPIR |
| 7 | *MSYQGKKSIPHITS |
Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413)
Protein Sequence
10
MSYQGKKSIP
20
HITSDRLLIK
30
GGRIINDDQS
40
LYADVYLEDG
50
LIKQIGENLI
60
VPGGVKTIEA
70
NGRMVIPGGI
80
DVNTYLQKPS
90
QGMTAADDFF
100
QGTRAALVGG
110
TTMIIDHVVP
120
EPGSSLLTSF
130
EKWHEAADTK
140
SCCDYSLHVD
150
ITSWYDGVRE
160
ELEVLVQDKG
170
VNSFQVYMAY
180
KDVYQMSDSQ
190
LYEAFTFLKG
200
LGAVILVHAE
210
NGDLIAQEQK
220
RILEMGITGP
230
EGHALSRPEE
240
LEAEAVFRAI
250
TIAGRINCPV
260
YITKVMSKSA
270
ADIIALARKK
280
GPLVFGEPIA
290
ASLGTDGTHY
300
WSKNWAKAAA
310
FVTSPPLSPD
320
PTTPDYLTSL
330
LACGDLQVTG
340
SGHCPYSTAQ
350
KAVGKDNFTL
360
IPEGVNGIEE
370
RMTVVWDKAV
380
ATGKMDENQF
390
VAVTSTNAAK
400
IFNLYPRKGR
410
IAVGSDADVV
420
IWDPDKLKTI
430
TAKSHKSAVE
440
YNIFEGMECH
450
GSPLVVISQG
460
KIVFEDGNIN
470
VNKGMGRFIP
480
RKAFPEHLYQ
490
RVKIRNKVFG
500
LQGVSRGMYD
510
GPVYEVPATP
520
KYATPAPSAK
530
SSPSKHQPPP
540
IRNLHQSNFS
550
LSGAQIDDNN
560
PRRTGHRIVA
570
PPGGRSNITS
LG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0031005 | filamin binding |
| Molecular Function | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.