Search Results

Overview

Uniprot ID	Q14195
Protein Name	Dihydropyrimidinase-related protein 3
Gene Name	DPYSL3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
480	PFSDYVYKRIKARRK
487	KRIKARRKMADLHAV

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Protein Sequence

10 MSYQGKKNIP 20 RITSDRLLIK 30 GGRIVNDDQS 40 FYADIYMEDG 50 LIKQIGDNLI 60 VPGGVKTIEA 70 NGKMVIPGGI 80 DVHTHFQMPY 90 KGMTTVDDFF 100 QGTKAALAGG 110 TTMIIDHVVP 120 EPESSLTEAY 130 EKWREWADGK 140 SCCDYALHVD 150 ITHWNDSVKQ 160 EVQNLIKDKG 170 VNSFMVYMAY 180 KDLYQVSNTE 190 LYEIFTCLGE 200 LGAIAQVHAE 210 NGDIIAQEQT 220 RMLEMGITGP 230 EGHVLSRPEE 240 LEAEAVFRAI 250 TIASQTNCPL 260 YVTKVMSKSA 270 ADLISQARKK 280 GNVVFGEPIT 290 ASLGIDGTHY 300 WSKNWAKAAA 310 FVTSPPLSPD 320 PTTPDYINSL 330 LASGDLQLSG 340 SAHCTFSTAQ 350 KAIGKDNFTA 360 IPEGTNGVEE 370 RMSVIWDKAV 380 ATGKMDENQF 390 VAVTSTNAAK 400 IFNLYPRKGR 410 ISVGSDSDLV 420 IWDPDAVKIV 430 SAKNHQSAAE 440 YNIFEGMELR 450 GAPLVVICQG 460 KIMLEDGNLH 470 VTQGAGRFIP 480 CSPFSDYVYK 490 RIKARRKMAD 500 LHAVPRGMYD 510 GPVFDLTTTP 520 KGGTPAGSAR 530 GSPTRPNPPV 540 RNLHQSGFSL 550 SGTQVDEGVR 560 SASKRIVAPP 570 GGRSNITSLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070382	exocytic vesicle
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0035374	chondroitin sulfate binding
Molecular Function	GO:0031005	filamin binding
Molecular Function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0051219	phosphoprotein binding
Molecular Function	GO:0017124	SH3 domain binding
Biological Process	GO:0051764	actin crosslink formation
Biological Process	GO:0051017	actin filament bundle assembly
Biological Process	GO:0071345	cellular response to cytokine stimulus
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:0048666	neuron development
Biological Process	GO:0051491	positive regulation of filopodium assembly
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0048678	response to axon injury

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.