Search Results

Overview

Uniprot IDQ14204
Protein NameCytoplasmic dynein 1 heavy chain 1
Gene NameDYNC1H1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1115 DYGKVQSKVNLKYDS
1496 GWDDLFNKVKEHINS
1610 RLADLLGKIQKALGE
1807 QPPLRRRKLEHLITE
1992 HSNPNYDKTSAPITC
2094 DFGLRALKSVLVSAG
2104 LVSAGNVKRERIQKI
2589 YTWLAEHKPLVLCGP
2601 CGPPGSGKTMTLFSA
3301 NAVKSIKKQHLVEVR
3471 DLAAVEAKVNRSTAL
3480 NRSTALLKSLSAERE
3621 FLDDAFRKNLESALR
371 LRKIRNTKYPIQRAL
3757 LQALNEVKGRILDDD
400 LKVLGTRKLMHVAYE
4089 KAINTAVKSGRWVML
4204 APLGWSKKYEFGESD
4406 KRTVENIKDPLFRFF
671 RVEDVLGKGWENHVE

Function

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074)

Protein Sequence

10 MSEPGGGGGE 20 DGSAGLEVSA 30 VQNVADVSVL 40 QKHLRKLVPL 50 LLEDGGEAPA 60 ALEAALEEKS 70 ALEQMRKFLS 80 DPQVHTVLVE 90 RSTLKEDVGD 100 EGEEEKEFIS 110 YNINIDIHYG 120 VKSNSLAFIK 130 RTPVIDADKP 140 VSSQLRVLTL 150 SEDSPYETLH 160 SFISNAVAPF 170 FKSYIRESGK 180 ADRDGDKMAP 190 SVEKKIAELE 200 MGLLHLQQNI 210 EIPEISLPIH 220 PMITNVAKQC 230 YERGEKPKVT 240 DFGDKVEDPT 250 FLNQLQSGVN 260 RWIREIQKVT 270 KLDRDPASGT 280 ALQEISFWLN 290 LERALYRIQE 300 KRESPEVLLT 310 LDILKHGKRF 320 HATVSFDTDT 330 GLKQALETVN 340 DYNPLMKDFP 350 LNDLLSATEL 360 DKIRQALVAI 370 FTHLRKIRNT 380 KYPIQRALRL 390 VEAISRDLSS 400 QLLKVLGTRK 410 LMHVAYEEFE 420 KVMVACFEVF 430 QTWDDEYEKL 440 QVLLRDIVKR 450 KREENLKMVW 460 RINPAHRKLQ 470 ARLDQMRKFR 480 RQHEQLRAVI 490 VRVLRPQVTA 500 VAQQNQGEVP 510 EPQDMKVAEV 520 LFDAADANAI 530 EEVNLAYENV 540 KEVDGLDVSK 550 EGTEAWEAAM 560 KRYDERIDRV 570 ETRITARLRD 580 QLGTAKNANE 590 MFRIFSRFNA 600 LFVRPHIRGA 610 IREYQTQLIQ 620 RVKDDIESLH 630 DKFKVQYPQS 640 QACKMSHVRD 650 LPPVSGSIIW 660 AKQIDRQLTA 670 YMKRVEDVLG 680 KGWENHVEGQ 690 KLKQDGDSFR 700 MKLNTQEIFD 710 DWARKVQQRN 720 LGVSGRIFTI 730 ESTRVRGRTG 740 NVLKLKVNFL 750 PEIITLSKEV 760 RNLKWLGFRV 770 PLAIVNKAHQ 780 ANQLYPFAIS 790 LIESVRTYER 800 TCEKVEERNT 810 ISLLVAGLKK 820 EVQALIAEGI 830 ALVWESYKLD 840 PYVQRLAETV 850 FNFQEKVDDL 860 LIIEEKIDLE 870 VRSLETCMYD 880 HKTFSEILNR 890 VQKAVDDLNL 900 HSYSNLPIWV 910 NKLDMEIERI 920 LGVRLQAGLR 930 AWTQVLLGQA 940 EDKAEVDMDT 950 DAPQVSHKPG 960 GEPKIKNVVH 970 ELRITNQVIY 980 LNPPIEECRY 990 KLYQEMFAWK 1000 MVVLSLPRIQ 1010 SQRYQVGVHY 1020 ELTEEEKFYR 1030 NALTRMPDGP 1040 VALEESYSAV 1050 MGIVSEVEQY 1060 VKVWLQYQCL 1070 WDMQAENIYN 1080 RLGEDLNKWQ 1090 ALLVQIRKAR 1100 GTFDNAETKK 1110 EFGPVVIDYG 1120 KVQSKVNLKY 1130 DSWHKEVLSK 1140 FGQMLGSNMT 1150 EFHSQISKSR 1160 QELEQHSVDT 1170 ASTSDAVTFI 1180 TYVQSLKRKI 1190 KQFEKQVELY 1200 RNGQRLLEKQ 1210 RFQFPPSWLY 1220 IDNIEGEWGA 1230 FNDIMRRKDS 1240 AIQQQVANLQ 1250 MKIVQEDRAV 1260 ESRTTDLLTD 1270 WEKTKPVTGN 1280 LRPEEALQAL 1290 TIYEGKFGRL 1300 KDDREKCAKA 1310 KEALELTDTG 1320 LLSGSEERVQ 1330 VALEELQDLK 1340 GVWSELSKVW 1350 EQIDQMKEQP 1360 WVSVQPRKLR 1370 QNLDALLNQL 1380 KSFPARLRQY 1390 ASYEFVQRLL 1400 KGYMKINMLV 1410 IELKSEALKD 1420 RHWKQLMKRL 1430 HVNWVVSELT 1440 LGQIWDVDLQ 1450 KNEAIVKDVL 1460 LVAQGEMALE 1470 EFLKQIREVW 1480 NTYELDLVNY 1490 QNKCRLIRGW 1500 DDLFNKVKEH 1510 INSVSAMKLS 1520 PYYKVFEEDA 1530 LSWEDKLNRI 1540 MALFDVWIDV 1550 QRRWVYLEGI 1560 FTGSADIKHL 1570 LPVETQRFQS 1580 ISTEFLALMK 1590 KVSKSPLVMD 1600 VLNIQGVQRS 1610 LERLADLLGK 1620 IQKALGEYLE 1630 RERSSFPRFY 1640 FVGDEDLLEI 1650 IGNSKNVAKL 1660 QKHFKKMFAG 1670 VSSIILNEDN 1680 SVVLGISSRE 1690 GEEVMFKTPV 1700 SITEHPKINE 1710 WLTLVEKEMR 1720 VTLAKLLAES 1730 VTEVEIFGKA 1740 TSIDPNTYIT 1750 WIDKYQAQLV 1760 VLSAQIAWSE 1770 NVETALSSMG 1780 GGGDAAPLHS 1790 VLSNVEVTLN 1800 VLADSVLMEQ 1810 PPLRRRKLEH 1820 LITELVHQRD 1830 VTRSLIKSKI 1840 DNAKSFEWLS 1850 QMRFYFDPKQ 1860 TDVLQQLSIQ 1870 MANAKFNYGF 1880 EYLGVQDKLV 1890 QTPLTDRCYL 1900 TMTQALEARL 1910 GGSPFGPAGT 1920 GKTESVKALG 1930 HQLGRFVLVF 1940 NCDETFDFQA 1950 MGRIFVGLCQ 1960 VGAWGCFDEF 1970 NRLEERMLSA 1980 VSQQVQCIQE 1990 ALREHSNPNY 2000 DKTSAPITCE 2010 LLNKQVKVSP 2020 DMAIFITMNP 2030 GYAGRSNLPD 2040 NLKKLFRSLA 2050 MTKPDRQLIA 2060 QVMLYSQGFR 2070 TAEVLANKIV 2080 PFFKLCDEQL 2090 SSQSHYDFGL 2100 RALKSVLVSA 2110 GNVKRERIQK 2120 IKREKEERGE 2130 AVDEGEIAEN 2140 LPEQEILIQS 2150 VCETMVPKLV 2160 AEDIPLLFSL 2170 LSDVFPGVQY 2180 HRGEMTALRE 2190 ELKKVCQEMY 2200 LTYGDGEEVG 2210 GMWVEKVLQL 2220 YQITQINHGL 2230 MMVGPSGSGK 2240 SMAWRVLLKA 2250 LERLEGVEGV 2260 AHIIDPKAIS 2270 KDHLYGTLDP 2280 NTREWTDGLF 2290 THVLRKIIDS 2300 VRGELQKRQW 2310 IVFDGDVDPE 2320 WVENLNSVLD 2330 DNKLLTLPNG 2340 ERLSLPPNVR 2350 IMFEVQDLKY 2360 ATLATVSRCG 2370 MVWFSEDVLS 2380 TDMIFNNFLA 2390 RLRSIPLDEG 2400 EDEAQRRRKG 2410 KEDEGEEAAS 2420 PMLQIQRDAA 2430 TIMQPYFTSN 2440 GLVTKALEHA 2450 FQLEHIMDLT 2460 RLRCLGSLFS 2470 MLHQACRNVA 2480 QYNANHPDFP 2490 MQIEQLERYI 2500 QRYLVYAILW 2510 SLSGDSRLKM 2520 RAELGEYIRR 2530 ITTVPLPTAP 2540 NIPIIDYEVS 2550 ISGEWSPWQA 2560 KVPQIEVETH 2570 KVAAPDVVVP 2580 TLDTVRHEAL 2590 LYTWLAEHKP 2600 LVLCGPPGSG 2610 KTMTLFSALR 2620 ALPDMEVVGL 2630 NFSSATTPEL 2640 LLKTFDHYCE 2650 YRRTPNGVVL 2660 APVQLGKWLV 2670 LFCDEINLPD 2680 MDKYGTQRVI 2690 SFIRQMVEHG 2700 GFYRTSDQTW 2710 VKLERIQFVG 2720 ACNPPTDPGR 2730 KPLSHRFLRH 2740 VPVVYVDYPG 2750 PASLTQIYGT 2760 FNRAMLRLIP 2770 SLRTYAEPLT 2780 AAMVEFYTMS 2790 QERFTQDTQP 2800 HYIYSPREMT 2810 RWVRGIFEAL 2820 RPLETLPVEG 2830 LIRIWAHEAL 2840 RLFQDRLVED 2850 EERRWTDENI 2860 DTVALKHFPN 2870 IDREKAMSRP 2880 ILYSNWLSKD 2890 YIPVDQEELR 2900 DYVKARLKVF 2910 YEEELDVPLV 2920 LFNEVLDHVL 2930 RIDRIFRQPQ 2940 GHLLLIGVSG 2950 AGKTTLSRFV 2960 AWMNGLSVYQ 2970 IKVHRKYTGE 2980 DFDEDLRTVL 2990 RRSGCKNEKI 3000 AFIMDESNVL 3010 DSGFLERMNT 3020 LLANGEVPGL 3030 FEGDEYATLM 3040 TQCKEGAQKE 3050 GLMLDSHEEL 3060 YKWFTSQVIR 3070 NLHVVFTMNP 3080 SSEGLKDRAA 3090 TSPALFNRCV 3100 LNWFGDWSTE 3110 ALYQVGKEFT 3120 SKMDLEKPNY 3130 IVPDYMPVVY 3140 DKLPQPPSHR 3150 EAIVNSCVFV 3160 HQTLHQANAR 3170 LAKRGGRTMA 3180 ITPRHYLDFI 3190 NHYANLFHEK 3200 RSELEEQQMH 3210 LNVGLRKIKE 3220 TVDQVEELRR 3230 DLRIKSQELE 3240 VKNAAANDKL 3250 KKMVKDQQEA 3260 EKKKVMSQEI 3270 QEQLHKQQEV 3280 IADKQMSVKE 3290 DLDKVEPAVI 3300 EAQNAVKSIK 3310 KQHLVEVRSM 3320 ANPPAAVKLA 3330 LESICLLLGE 3340 STTDWKQIRS 3350 IIMRENFIPT 3360 IVNFSAEEIS 3370 DAIREKMKKN 3380 YMSNPSYNYE 3390 IVNRASLACG 3400 PMVKWAIAQL 3410 NYADMLKRVE 3420 PLRNELQKLE 3430 DDAKDNQQKA 3440 NEVEQMIRDL 3450 EASIARYKEE 3460 YAVLISEAQA 3470 IKADLAAVEA 3480 KVNRSTALLK 3490 SLSAERERWE 3500 KTSETFKNQM 3510 STIAGDCLLS 3520 AAFIAYAGYF 3530 DQQMRQNLFT 3540 TWSHHLQQAN 3550 IQFRTDIART 3560 EYLSNADERL 3570 RWQASSLPAD 3580 DLCTENAIML 3590 KRFNRYPLII 3600 DPSGQATEFI 3610 MNEYKDRKIT 3620 RTSFLDDAFR 3630 KNLESALRFG 3640 NPLLVQDVES 3650 YDPVLNPVLN 3660 REVRRTGGRV 3670 LITLGDQDID 3680 LSPSFVIFLS 3690 TRDPTVEFPP 3700 DLCSRVTFVN 3710 FTVTRSSLQS 3720 QCLNEVLKAE 3730 RPDVDEKRSD 3740 LLKLQGEFQL 3750 RLRQLEKSLL 3760 QALNEVKGRI 3770 LDDDTIITTL 3780 ENLKREAAEV 3790 TRKVEETDIV 3800 MQEVETVSQQ 3810 YLPLSTACSS 3820 IYFTMESLKQ 3830 IHFLYQYSLQ 3840 FFLDIYHNVL 3850 YENPNLKGVT 3860 DHTQRLSIIT 3870 KDLFQVAFNR 3880 VARGMLHQDH 3890 ITFAMLLARI 3900 KLKGTVGEPT 3910 YDAEFQHFLR 3920 GNEIVLSAGS 3930 TPRIQGLTVE 3940 QAEAVVRLSC 3950 LPAFKDLIAK 3960 VQADEQFGIW 3970 LDSSSPEQTV 3980 PYLWSEETPA 3990 TPIGQAIHRL 4000 LLIQAFRPDR 4010 LLAMAHMFVS 4020 TNLGESFMSI 4030 MEQPLDLTHI 4040 VGTEVKPNTP 4050 VLMCSVPGYD 4060 ASGHVEDLAA 4070 EQNTQITSIA 4080 IGSAEGFNQA 4090 DKAINTAVKS 4100 GRWVMLKNVH 4110 LAPGWLMQLE 4120 KKLHSLQPHA 4130 CFRLFLTMEI 4140 NPKVPVNLLR 4150 AGRIFVFEPP 4160 PGVKANMLRT 4170 FSSIPVSRIC 4180 KSPNERARLY 4190 FLLAWFHAII 4200 QERLRYAPLG 4210 WSKKYEFGES 4220 DLRSACDTVD 4230 TWLDDTAKGR 4240 QNISPDKIPW 4250 SALKTLMAQS 4260 IYGGRVDNEF 4270 DQRLLNTFLE 4280 RLFTTRSFDS 4290 EFKLACKVDG 4300 HKDIQMPDGI 4310 RREEFVQWVE 4320 LLPDTQTPSW 4330 LGLPNNAERV 4340 LLTTQGVDMI 4350 SKMLKMQMLE 4360 DEDDLAYAET 4370 EKKTRTDSTS 4380 DGRPAWMRTL 4390 HTTASNWLHL 4400 IPQTLSHLKR 4410 TVENIKDPLF 4420 RFFEREVKMG 4430 AKLLQDVRQD 4440 LADVVQVCEG 4450 KKKQTNYLRT 4460 LINELVKGIL 4470 PRSWSHYTVP 4480 AGMTVIQWVS 4490 DFSERIKQLQ 4500 NISLAAASGG 4510 AKELKNIHVC 4520 LGGLFVPEAY 4530 ITATRQYVAQ 4540 ANSWSLEELC 4550 LEVNVTTSQG 4560 ATLDACSFGV 4570 TGLKLQGATC 4580 NNNKLSLSNA 4590 ISTALPLTQL 4600 RWVKQTNTEK 4610 KASVVTLPVY 4620 LNFTRADLIF 4630 TVDFEIATKE 4640 DPRSFYERGV AVLCTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005868 cytoplasmic dynein complex
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0030175 filopodium
Cellular Component GO:0001673 male germ cell nucleus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0051301 cell division
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0051293 establishment of spindle localization
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007097 nuclear migration
Biological Process GO:0033962 P-body assembly
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0032388 positive regulation of intracellular transport
Biological Process GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process GO:1905832 positive regulation of spindle assembly
Biological Process GO:0090235 regulation of metaphase plate congression
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0008090 retrograde axonal transport
Biological Process GO:0034063 stress granule assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.