Search Results

Overview

Uniprot IDQ14207
Protein NameProtein NPAT
Gene NameNPAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1130 PLPKILSKSESAISR

Function

Transcription regulator required for progression through the G1 and S phases of the cell cycle and for S phase entry (PubMed:12665581, PubMed:15555599, PubMed:9472014). Acts as a key transcription regulator of histones (PubMed:10995386, PubMed:10995387, PubMed:12724424, PubMed:14585971, PubMed:14612403, PubMed:15988025, PubMed:16131487, PubMed:17163457, PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:10995386, PubMed:10995387, PubMed:12724424, PubMed:14585971, PubMed:14612403, PubMed:15988025, PubMed:16131487, PubMed:17163457, PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also positively regulates the ATM, MIZF and PRKDC promoters (PubMed:17826007, PubMed:17974976, PubMed:8743993, PubMed:8923007). Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (PubMed:17967892)

Protein Sequence

10 MLLPSDVARL 20 VLGYLQQENL 30 ISTCQTFILE 40 SSDLKEYAEH 50 CTDEGFIPAC 60 LLSLFGKNLT 70 TILNEYVAMK 80 TKETSNNVPA 90 IMSSLWKKLD 100 HTLSQIRSMQ 110 SSPRFAGSQR 120 ARTRTGIAEI 130 KRQRKLASQT 140 APASAELLTL 150 PYLSGQFTTP 160 PSTGTQVTRP 170 SGQISDPSRS 180 YFVVVNHSQS 190 QDTVTTGEAL 200 NVIPGAQEKK 210 AHASLMSPGR 220 RKSESQRKST 230 TLSGPHSTIR 240 NFQDPNAFAV 250 EKQMVIENAR 260 EKILSNKSLQ 270 EKLAENINKF 280 LTSDNNIAQV 290 PKQTDNNPTE 300 PETSIDEFLG 310 LPSEIHMSEE 320 AIQDILEQTE 330 SDPAFQALFD 340 LFDYGKTKNN 350 KNISQSISSQ 360 PMESNPSIVL 370 ADETNLAVKG 380 SFETEESDGQ 390 SGQPAFCTSY 400 QNDDPLNALK 410 NSNNHDVLRQ 420 EDQENFSQIS 430 TSIQKKAFKT 440 AVPTEQKCDI 450 DITFESVPNL 460 NDFNQRGNSN 470 AECNPHCAEL 480 YTNQMSTETE 490 MAIGIEKNSL 500 SSNVPSESQL 510 QPDQPDIPIT 520 SFVSLGCEAN 530 NENLILSGKS 540 SQLLSQDTSL 550 TGKPSKKSQF 560 CENSNDTVKL 570 KINFHGSKSS 580 DSSEVHKSKI 590 EINVLEPVMS 600 QLSNCQDNSC 610 LQSEILPVSV 620 ESSHLNVSGQ 630 VEIHLGDSLS 640 STKQPSNDSA 650 SVELNHTENE 660 AQASKSENSQ 670 EPSSSVKEEN 680 TIFLSLGGNA 690 NCEKVALTPP 700 EGTPVENSHS 710 LPPESVCSSV 720 GDSHPESQNT 730 DDKPSSNNSA 740 EIDASNIVSL 750 KVIISDDPFV 760 SSDTELTSAV 770 SSINGENLPT 780 IILSSPTKSP 790 TKNAELVKCL 800 SSEETVGAVV 810 YAEVGDSASM 820 EQSLLTFKSE 830 DSAVNNTQNE 840 DGIAFSANVT 850 PCVSKDGGYI 860 QLMPATSTAF 870 GNSNNILIAT 880 CVTDPTALGT 890 SVSQSNVVVL 900 PGNSAPMTAQ 910 PLPPQLQTPP 920 RSNSVFAVNQ 930 AVSPNFSQGS 940 AIIIASPVQP 950 VLQGMVGMIP 960 VSVVGQNGNN 970 FSTPPRQVLH 980 MPLTAPVCNR 990 SIPQFPVPPK 1000 SQKAQGLRNK 1010 PCIGKQVNNL 1020 VDSSGHSVGC 1030 HAQKTEVSDK 1040 SIATDLGKKS 1050 EETTVPFPEE 1060 SIVPAAKPCH 1070 RRVLCFDSTT 1080 APVANTQGPN 1090 HKMVSQNKER 1100 NAVSFPNLDS 1110 PNVSSTLKPP 1120 SNNAIKREKE 1130 KPPLPKILSK 1140 SESAISRHTT 1150 IRETQSEKKV 1160 SPTEIVLESF 1170 HKATANKENE 1180 LCSDVERQKN 1190 PENSKLSIGQ 1200 QNGGLRSEKS 1210 IASLQEMTKK 1220 QGTSSNNKNV 1230 LSVGTAVKDL 1240 KQEQTKSASS 1250 LITTEMLQDI 1260 QRHSSVSRLA 1270 DSSDLPVPRT 1280 PGSGAGEKHK 1290 EEPIDIIKAP 1300 SSRRFSEDSS 1310 TSKVMVPPVT 1320 PDLPACSPAS 1330 ETGSENSVNM 1340 AAHTLMILSR 1350 AAISRTTSAT 1360 PLKDNTQQFR 1370 ASSRSTTKKR 1380 KIEELDERER 1390 NSRPSSKNLT 1400 NSSIPMKKKK 1410 IKKKKLPSSF 1420 PAGMDVDKFL LSLHYDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0097504 Gemini of Cajal bodies
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0044843 cell cycle G1/S phase transition
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

PMID: N/A