Overview
| Uniprot ID | Q14232 |
|---|
| Protein Name | Translation initiation factor eIF2B subunit alpha |
|---|
| Gene Name | EIF2B1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 146 |
EAAVAAKKRFSVYVT |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)
Protein Sequence
10
MDDKELIEYF
20
KSQMKEDPDM
30
ASAVAAIRTL
40
LEFLKRDKGE
50
TIQGLRANLT
60
SAIETLCGVD
70
SSVAVSSGGE
80
LFLRFISLAS
90
LEYSDYSKCK
100
KIMIERGELF
110
LRRISLSRNK
120
IADLCHTFIK
130
DGATILTHAY
140
SRVVLRVLEA
150
AVAAKKRFSV
160
YVTESQPDLS
170
GKKMAKALCH
180
LNVPVTVVLD
190
AAVGYIMEKA
200
DLVIVGAEGV
210
VENGGIINKI
220
GTNQMAVCAK
230
AQNKPFYVVA
240
ESFKFVRLFP
250
LNQQDVPDKF
260
KYKADTLKVA
270
QTGQDLKEEH
280
PWVDYTAPSL
290
ITLLFTDLGV
300
LTPSAVSDEL
IKLYL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005851 |
eukaryotic translation initiation factor 2B complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0002183 |
cytoplasmic translational initiation |
| Biological Process |
GO:0014003 |
oligodendrocyte development |
| Biological Process |
GO:0045948 |
positive regulation of translational initiation |
| Biological Process |
GO:0009749 |
response to glucose |
| Biological Process |
GO:0009408 |
response to heat |
| Biological Process |
GO:0043434 |
response to peptide hormone |
| Biological Process |
GO:0050852 |
T cell receptor signaling pathway |
| Biological Process |
GO:0006413 |
translational initiation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.