Search Results

Overview

Uniprot ID	Q14240
Protein Name	Eukaryotic initiation factor 4A-II
Gene Name	EIF4A2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
147	NVRNEMQKLQAEAPH
370	RGGRFGRKGVAINFV
69	RAIIPCIKGYDVIAQ

Function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

Protein Sequence

10 MSGGSADYNR 20 EHGGPEGMDP 30 DGVIESNWNE 40 IVDNFDDMNL 50 KESLLRGIYA 60 YGFEKPSAIQ 70 QRAIIPCIKG 80 YDVIAQAQSG 90 TGKTATFAIS 100 ILQQLEIEFK 110 ETQALVLAPT 120 RELAQQIQKV 130 ILALGDYMGA 140 TCHACIGGTN 150 VRNEMQKLQA 160 EAPHIVVGTP 170 GRVFDMLNRR 180 YLSPKWIKMF 190 VLDEADEMLS 200 RGFKDQIYEI 210 FQKLNTSIQV 220 VLLSATMPTD 230 VLEVTKKFMR 240 DPIRILVKKE 250 ELTLEGIKQF 260 YINVEREEWK 270 LDTLCDLYET 280 LTITQAVIFL 290 NTRRKVDWLT 300 EKMHARDFTV 310 SALHGDMDQK 320 ERDVIMREFR 330 SGSSRVLITT 340 DLLARGIDVQ 350 QVSLVINYDL 360 PTNRENYIHR 370 IGRGGRFGRK 380 GVAINFVTEE 390 DKRILRDIET 400 FYNTTVEEMP MNVADLI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0004386	helicase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003724	RNA helicase activity
Molecular Function	GO:0003743	translation initiation factor activity
Biological Process	GO:0002183	cytoplasmic translational initiation
Biological Process	GO:1900260	negative regulation of RNA-dependent RNA polymerase activity
Biological Process	GO:0006446	regulation of translational initiation
Biological Process	GO:0006413	translational initiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.