Search Results

Overview

Uniprot IDQ14241
Protein NameElongin-A
Gene NameELOA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
262 VDAKSDEKASVVSRE
383 VKTNLDRKSLGSLPK
425 KKKKKIVKTSATALG
434 SATALGDKGLKKNDS
437 ALGDKGLKKNDSKST
446 NDSKSTGKNLDSVQK
453 KNLDSVQKLPKVNKT
472 PAGADLAKLRKVPDV
512 SSFQPKRKAFSSPQE
693 GGAAVPEKIKIKPAP
695 AAVPEKIKIKPAPYP

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)

Protein Sequence

10 MAAESALQVV 20 EKLQARLAAN 30 PDPKKLLKYL 40 KKLSTLPITV 50 DILAETGVGK 60 TVNSLRKHEH 70 VGSFARDLVA 80 QWKKLVPVER 90 NAEPDEQDFE 100 KSNSRKRPRD 110 ALQKEEEMEG 120 DYQETWKATG 130 SRSYSPDHRQ 140 KKHRKLSELE 150 RPHKVSHGHE 160 RRDERKRCHR 170 MSPTYSSDPE 180 SSDYGHVQSP 190 PSCTSPHQMY 200 VDHYRSLEED 210 QEPIVSHQKP 220 GKGHSNAFQD 230 RLGASQERHL 240 GEPHGKGVVS 250 QNKEHKSSHK 260 DKRPVDAKSD 270 EKASVVSREK 280 SHKALSKEEN 290 RRPPSGDNAR 300 EKPPSSGVKK 310 EKDREGSSLK 320 KKCLPPSEAA 330 SDNHLKKPKH 340 RDPEKAKLDK 350 SKQGLDSFDT 360 GKGAGDLLPK 370 VKEKGSNNLK 380 TPEGKVKTNL 390 DRKSLGSLPK 400 VEETDMEDEF 410 EQPTMSFESY 420 LSYDQPRKKK 430 KKIVKTSATA 440 LGDKGLKKND 450 SKSTGKNLDS 460 VQKLPKVNKT 470 KSEKPAGADL 480 AKLRKVPDVL 490 PVLPDLPLPA 500 IQANYRPLPS 510 LELISSFQPK 520 RKAFSSPQEE 530 EEAGFTGRRM 540 NSKMQVYSGS 550 KCAYLPKMMT 560 LHQQCIRVLK 570 NNIDSIFEVG 580 GVPYSVLEPV 590 LERCTPDQLY 600 RIEEYNHVLI 610 EETDQLWKVH 620 CHRDFKEERP 630 EEYESWREMY 640 LRLQDAREQR 650 LRVLTKNIQF 660 AHANKPKGRQ 670 AKMAFVNSVA 680 KPPRDVRRRQ 690 EKFGTGGAAV 700 PEKIKIKPAP 710 YPMGSSHASA 720 SSISFNPSPE 730 EPAYDGPSTS 740 SAHLAPVVSS 750 TVSYDPRKPT 760 VKKIAPMMAK 770 TIKAFKNRFS RR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070449 elongin complex
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0090734 site of DNA damage
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006368 transcription elongation by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.