Search Results
Overview
| Uniprot ID | Q14242 |
|---|---|
| Protein Name | P-selectin glycoprotein ligand 1 |
| Gene Name | SELPLG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 348 | LAVRLSRKGHMYPVR |
Function
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture
Protein Sequence
10
MPLQLLLLLI
20
LLGPGNSLQL
30
WDTWADEAEK
40
ALGPLLARDR
50
RQATEYEYLD
60
YDFLPETEPP
70
EMLRNSTDTT
80
PLTGPGTPES
90
TTVEPAARRS
100
TGLDAGGAVT
110
ELTTELANMG
120
NLSTDSAAME
130
IQTTQPAATE
140
AQTTQPVPTE
150
AQTTPLAATE
160
AQTTRLTATE
170
AQTTPLAATE
180
AQTTPPAATE
190
AQTTQPTGLE
200
AQTTAPAAME
210
AQTTAPAAME
220
AQTTPPAAME
230
AQTTQTTAME
240
AQTTAPEATE
250
AQTTQPTATE
260
AQTTPLAAME
270
ALSTEPSATE
280
ALSMEPTTKR
290
GLFIPFSVSS
300
VTHKGIPMAA
310
SNLSVNYPVG
320
APDHISVKQC
330
LLAILILALV
340
ATIFFVCTVV
350
LAVRLSRKGH
360
MYPVRNYSPT
370
EMVCISSLLP
380
DGGEGPSATA
390
NGGLSKAKSP
400
GLTPEPREDR
410
EGDDLTLHSF
LP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0001931 | uropod |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0050902 | leukocyte adhesive activation |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0050901 | leukocyte tethering or rolling |
Reference
PMID: N/A