Search Results

Overview

Uniprot IDQ14247
Protein NameSrc substrate cortactin
Gene NameCTTN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 VGHEYQSKLSKHCSQ
110 EYQSKLSKHCSQVDS
124 SVRGFGGKFGVQMDR
144 VGFEYQGKTEKHASQ
147 EYQGKTEKHASQKDY
152 TEKHASQKDYSSGFG
161 YSSGFGGKYGVQADR
171 VQADRVDKSAVGFDY
181 VGFDYQGKTEKHESQ
184 DYQGKTEKHESQRDY
193 ESQRDYSKGFGGKYG
198 YSKGFGGKYGIDKDK
203 GGKYGIDKDKVDKSA
205 KYGIDKDKVDKSAVG
208 IDKDKVDKSAVGFEY
218 VGFEYQGKTEKHESQ
226 TEKHESQKDYVKGFG
230 ESQKDYVKGFGGKFG
235 YVKGFGGKFGVQTDR
245 VQTDRQDKCALGWDH
263 LQLHESQKDYKTGFG
266 HESQKDYKTGFGGKF
272 YKTGFGGKFGVQSER
290 AAVGFDYKEKLAKHE
295 DYKEKLAKHESQQDY
304 ESQQDYSKGFGGKYG
309 YSKGFGGKYGVQKDR
314 GGKYGVQKDRMDKNA
319 VQKDRMDKNASTFED
336 QVSSAYQKTVPVEAV
346 PVEAVTSKTSNIRAN
359 ANFENLAKEKEQEDR
398 LEEQARAKTQTPPVS
42 KEQRWGAKTVQGSGH
57 QEHINIHKLRENVFQ
70 FQEHQTLKEKELETG
72 EHQTLKEKELETGPK
79 KELETGPKASHGYGG
87 ASHGYGGKFGVEQDR
97 VEQDRMDKSAVGHEY

Function

Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290)

Protein Sequence

10 MWKASAGHAV 20 SIAQDDAGAD 30 DWETDPDFVN 40 DVSEKEQRWG 50 AKTVQGSGHQ 60 EHINIHKLRE 70 NVFQEHQTLK 80 EKELETGPKA 90 SHGYGGKFGV 100 EQDRMDKSAV 110 GHEYQSKLSK 120 HCSQVDSVRG 130 FGGKFGVQMD 140 RVDQSAVGFE 150 YQGKTEKHAS 160 QKDYSSGFGG 170 KYGVQADRVD 180 KSAVGFDYQG 190 KTEKHESQRD 200 YSKGFGGKYG 210 IDKDKVDKSA 220 VGFEYQGKTE 230 KHESQKDYVK 240 GFGGKFGVQT 250 DRQDKCALGW 260 DHQEKLQLHE 270 SQKDYKTGFG 280 GKFGVQSERQ 290 DSAAVGFDYK 300 EKLAKHESQQ 310 DYSKGFGGKY 320 GVQKDRMDKN 330 ASTFEDVTQV 340 SSAYQKTVPV 350 EAVTSKTSNI 360 RANFENLAKE 370 KEQEDRRKAE 380 AERAQRMAKE 390 RQEQEEARRK 400 LEEQARAKTQ 410 TPPVSPAPQP 420 TEERLPSSPV 430 YEDAASFKAE 440 LSYRGPVSGT 450 EPEPVYSMEA 460 ADYREASSQQ 470 GLAYATEAVY 480 ESAEAPGHYP 490 AEDSTYDEYE 500 NDLGITAVAL 510 YDYQAAGDDE 520 ISFDPDDIIT 530 NIEMIDDGWW 540 RGVCKGRYGL 550 FPANYVELRQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030426 growth cone
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:1990023 mitotic spindle midzone
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0098871 postsynaptic actin cytoskeleton
Cellular Component GO:0001726 ruffle
Cellular Component GO:0008076 voltage-gated potassium channel complex
Molecular Function GO:0071933 Arp2/3 complex binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0070064 proline-rich region binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0048870 cell motility
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0097581 lamellipodium organization
Biological Process GO:0098885 modification of postsynaptic actin cytoskeleton
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0050921 positive regulation of chemotaxis
Biological Process GO:0045987 positive regulation of smooth muscle contraction
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0030516 regulation of axon extension
Biological Process GO:0060491 regulation of cell projection assembly
Biological Process GO:1901524 regulation of mitophagy
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.