Search Results
Overview
| Uniprot ID | Q14254 |
|---|---|
| Protein Name | Flotillin-2 |
| Gene Name | FLOT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 307 | IAEGEKVKQVLLAQA |
| 344 | EAERMKLKAEAYQKY |
| 350 | LKAEAYQKYGDAAKM |
Function
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function
Protein Sequence
10
MGNCHTVGPN
20
EALVVSGGCC
30
GSDYKQYVFG
40
GWAWAWWCIS
50
DTQRISLEIM
60
TLQPRCEDVE
70
TAEGVALTVT
80
GVAQVKIMTE
90
KELLAVACEQ
100
FLGKNVQDIK
110
NVVLQTLEGH
120
LRSILGTLTV
130
EQIYQDRDQF
140
AKLVREVAAP
150
DVGRMGIEIL
160
SFTIKDVYDK
170
VDYLSSLGKT
180
QTAVVQRDAD
190
IGVAEAERDA
200
GIREAECKKE
210
MLDVKFMADT
220
KIADSKRAFE
230
LQKSAFSEEV
240
NIKTAEAQLA
250
YELQGAREQQ
260
KIRQEEIEIE
270
VVQRKKQIAV
280
EAQEILRTDK
290
ELIATVRRPA
300
EAEAHRIQQI
310
AEGEKVKQVL
320
LAQAEAEKIR
330
KIGEAEAAVI
340
EAMGKAEAER
350
MKLKAEAYQK
360
YGDAAKMALV
370
LEALPQIAAK
380
IAAPLTKVDE
390
IVVLSGDNSK
400
VTSEVNRLLA
410
ELPASVHALT
420
GVDLSKIPLI
KKATGVQV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016600 | flotillin complex |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001931 | uropod |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0098937 | anterograde dendritic transport |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:1902992 | negative regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:1903905 | positive regulation of establishment of T cell polarity |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0044860 | protein localization to plasma membrane raft |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0045661 | regulation of myoblast differentiation |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.