Search Results

Overview

Uniprot IDQ14315
Protein NameFilamin-C
Gene NameFLNC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1014 SRRPIPCKLEPGGGA
113 FLEREHIKLVSIDSK
120 KLVSIDSKAIVDGNL
1935 IIVRFDDKHIPGSPF
2195 TERTEISKTRGGETK
2463 VSELDSDKHTIRFIP
2630 SSYSSIPKFSSDASK
510 GAGSGELKVTVKGPK
911 VQFAGTAKGEVVRDF

Function

Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity)

Protein Sequence

10 MMNNSGYSDA 20 GLGLGDETDE 30 MPSTEKDLAE 40 DAPWKKIQQN 50 TFTRWCNEHL 60 KCVGKRLTDL 70 QRDLSDGLRL 80 IALLEVLSQK 90 RMYRKFHPRP 100 NFRQMKLENV 110 SVALEFLERE 120 HIKLVSIDSK 130 AIVDGNLKLI 140 LGLIWTLILH 150 YSISMPMWED 160 EDDEDARKQT 170 PKQRLLGWIQ 180 NKVPQLPITN 190 FNRDWQDGKA 200 LGALVDNCAP 210 GLCPDWEAWD 220 PNQPVENARE 230 AMQQADDWLG 240 VPQVIAPEEI 250 VDPNVDEHSV 260 MTYLSQFPKA 270 KLKPGAPVRS 280 KQLNPKKAIA 290 YGPGIEPQGN 300 TVLQPAHFTV 310 QTVDAGVGEV 320 LVYIEDPEGH 330 TEEAKVVPNN 340 DKDRTYAVSY 350 VPKVAGLHKV 360 TVLFAGQNIE 370 RSPFEVNVGM 380 ALGDANKVSA 390 RGPGLEPVGN 400 VANKPTYFDI 410 YTAGAGTGDV 420 AVVIVDPQGR 430 RDTVEVALED 440 KGDSTFRCTY 450 RPAMEGPHTV 460 HVAFAGAPIT 470 RSPFPVHVSE 480 ACNPNACRAS 490 GRGLQPKGVR 500 VKEVADFKVF 510 TKGAGSGELK 520 VTVKGPKGTE 530 EPVKVREAGD 540 GVFECEYYPV 550 VPGKYVVTIT 560 WGGYAIPRSP 570 FEVQVSPEAG 580 VQKVRAWGPG 590 LETGQVGKSA 600 DFVVEAIGTE 610 VGTLGFSIEG 620 PSQAKIECDD 630 KGDGSCDVRY 640 WPTEPGEYAV 650 HVICDDEDIR 660 DSPFIAHILP 670 APPDCFPDKV 680 KAFGPGLEPT 690 GCIVDKPAEF 700 TIDARAAGKG 710 DLKLYAQDAD 720 GCPIDIKVIP 730 NGDGTFRCSY 740 VPTKPIKHTI 750 IISWGGVNVP 760 KSPFRVNVGE 770 GSHPERVKVY 780 GPGVEKTGLK 790 ANEPTYFTVD 800 CSEAGQGDVS 810 IGIKCAPGVV 820 GPAEADIDFD 830 IIKNDNDTFT 840 VKYTPPGAGR 850 YTIMVLFANQ 860 EIPASPFHIK 870 VDPSHDASKV 880 KAEGPGLNRT 890 GVEVGKPTHF 900 TVLTKGAGKA 910 KLDVQFAGTA 920 KGEVVRDFEI 930 IDNHDYSYTV 940 KYTAVQQGNM 950 AVTVTYGGDP 960 VPKSPFVVNV 970 APPLDLSKIK 980 VQGLNSKVAV 990 GQEQAFSVNT 1000 RGAGGQGQLD 1010 VRMTSPSRRP 1020 IPCKLEPGGG 1030 AEAQAVRYMP 1040 PEEGPYKVDI 1050 TYDGHPVPGS 1060 PFAVEGVLPP 1070 DPSKVCAYGP 1080 GLKGGLVGTP 1090 APFSIDTKGA 1100 GTGGLGLTVE 1110 GPCEAKIECQ 1120 DNGDGSCAVS 1130 YLPTEPGEYT 1140 INILFAEAHI 1150 PGSPFKATIR 1160 PVFDPSKVRA 1170 SGPGLERGKV 1180 GEAATFTVDC 1190 SEAGEAELTI 1200 EILSDAGVKA 1210 EVLIHNNADG 1220 TYHITYSPAF 1230 PGTYTITIKY 1240 GGHPVPKFPT 1250 RVHVQPAVDT 1260 SGVKVSGPGV 1270 EPHGVLREVT 1280 TEFTVDARSL 1290 TATGGNHVTA 1300 RVLNPSGAKT 1310 DTYVTDNGDG 1320 TYRVQYTAYE 1330 EGVHLVEVLY 1340 DEVAVPKSPF 1350 RVGVTEGCDP 1360 TRVRAFGPGL 1370 EGGLVNKANR 1380 FTVETRGAGT 1390 GGLGLAIEGP 1400 SEAKMSCKDN 1410 KDGSCTVEYI 1420 PFTPGDYDVN 1430 ITFGGRPIPG 1440 SPFRVPVKDV 1450 VDPGKVKCSG 1460 PGLGAGVRAR 1470 VPQTFTVDCS 1480 QAGRAPLQVA 1490 VLGPTGVAEP 1500 VEVRDNGDGT 1510 HTVHYTPATD 1520 GPYTVAVKYA 1530 DQEVPRSPFK 1540 IKVLPAHDAS 1550 KVRASGPGLN 1560 ASGIPASLPV 1570 EFTIDARDAG 1580 EGLLTVQILD 1590 PEGKPKKANI 1600 RDNGDGTYTV 1610 SYLPDMSGRY 1620 TITIKYGGDE 1630 IPYSPFRIHA 1640 LPTGDASKCL 1650 VTVSIGGHGL 1660 GACLGPRIQI 1670 GQETVITVDA 1680 KAAGEGKVTC 1690 TVSTPDGAEL 1700 DVDVVENHDG 1710 TFDIYYTAPE 1720 PGKYVITIRF 1730 GGEHIPNSPF 1740 HVLACDPLPH 1750 EEEPSEVPQL 1760 RQPYAPPRPG 1770 ARPTHWATEE 1780 PVVPVEPMES 1790 MLRPFNLVIP 1800 FAVQKGELTG 1810 EVRMPSGKTA 1820 RPNITDNKDG 1830 TITVRYAPTE 1840 KGLHQMGIKY 1850 DGNHIPGSPL 1860 QFYVDAINSR 1870 HVSAYGPGLS 1880 HGMVNKPATF 1890 TIVTKDAGEG 1900 GLSLAVEGPS 1910 KAEITCKDNK 1920 DGTCTVSYLP 1930 TAPGDYSIIV 1940 RFDDKHIPGS 1950 PFTAKITGDD 1960 SMRTSQLNVG 1970 TSTDVSLKIT 1980 ESDLSQLTAS 1990 IRAPSGNEEP 2000 CLLKRLPNRH 2010 IGISFTPKEV 2020 GEHVVSVRKS 2030 GKHVTNSPFK 2040 ILVGPSEIGD 2050 ASKVRVWGKG 2060 LSEGHTFQVA 2070 EFIVDTRNAG 2080 YGGLGLSIEG 2090 PSKVDINCED 2100 MEDGTCKVTY 2110 CPTEPGTYII 2120 NIKFADKHVP 2130 GSPFTVKVTG 2140 EGRMKESITR 2150 RRQAPSIATI 2160 GSTCDLNLKI 2170 PGNWFQMVSA 2180 QERLTRTFTR 2190 SSHTYTRTER 2200 TEISKTRGGE 2210 TKREVRVEES 2220 TQVGGDPFPA 2230 VFGDFLGRER 2240 LGSFGSITRQ 2250 QEGEASSQDM 2260 TAQVTSPSGK 2270 VEAAEIVEGE 2280 DSAYSVRFVP 2290 QEMGPHTVAV 2300 KYRGQHVPGS 2310 PFQFTVGPLG 2320 EGGAHKVRAG 2330 GTGLERGVAG 2340 VPAEFSIWTR 2350 EAGAGGLSIA 2360 VEGPSKAEIA 2370 FEDRKDGSCG 2380 VSYVVQEPGD 2390 YEVSIKFNDE 2400 HIPDSPFVVP 2410 VASLSDDARR 2420 LTVTSLQETG 2430 LKVNQPASFA 2440 VQLNGARGVI 2450 DARVHTPSGA 2460 VEECYVSELD 2470 SDKHTIRFIP 2480 HENGVHSIDV 2490 KFNGAHIPGS 2500 PFKIRVGEQS 2510 QAGDPGLVSA 2520 YGPGLEGGTT 2530 GVSSEFIVNT 2540 LNAGSGALSV 2550 TIDGPSKVQL 2560 DCRECPEGHV 2570 VTYTPMAPGN 2580 YLIAIKYGGP 2590 QHIVGSPFKA 2600 KVTGPRLSGG 2610 HSLHETSTVL 2620 VETVTKSSSS 2630 RGSSYSSIPK 2640 FSSDASKVVT 2650 RGPGLSQAFV 2660 GQKNSFTVDC 2670 SKAGTNMMMV 2680 GVHGPKTPCE 2690 EVYVKHMGNR 2700 VYNVTYTVKE 2710 KGDYILIVKW 2720 GDESVPGSPF KVKVP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043034 costamere
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016528 sarcoplasm
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0045214 sarcomere organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.