Search Results

Overview

Uniprot IDQ14320
Protein NameProtein FAM50A
Gene NameFAM50A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 QSKELQMKLEKLREK
103 ELQMKLEKLREKERK
152 EREEITTKKRKLGKN
153 REEITTKKRKLGKNP
158 TKKRKLGKNPDVDTS
19 GRAMHLMKKREKQRE
20 RAMHLMKKREKQREQ
275 IVTKARGKSGPLFNF
298 LSDATVEKDESHAGK
32 REQMEQMKQRIAEEN
335 DPEKKWDKYTIR***
42 IAEENIMKSNIDKKF
48 MKSNIDKKFSAHYDA
5 ***MAQYKGAASEAG
74 LVTLNDMKAKQEALV
76 TLNDMKAKQEALVKE
82 AKQEALVKEREKQLA
95 LAKKEQSKELQMKLE

Function

Probably involved in the regulation of pre-mRNA splicing

Protein Sequence

10 MAQYKGAASE 20 AGRAMHLMKK 30 REKQREQMEQ 40 MKQRIAEENI 50 MKSNIDKKFS 60 AHYDAVEAEL 70 KSSTVGLVTL 80 NDMKAKQEAL 90 VKEREKQLAK 100 KEQSKELQMK 110 LEKLREKERK 120 KEAKRKISSL 130 SFTLEEEEEG 140 GEEEEEAAMY 150 EEEMEREEIT 160 TKKRKLGKNP 170 DVDTSFLPDR 180 DREEEENRLR 190 EELRQEWEAK 200 QEKIKSEEIE 210 ITFSYWDGSG 220 HRRTVKMRKG 230 NTMQQFLQKA 240 LEILRKDFSE 250 LRSAGVEQLM 260 YIKEDLIIPH 270 HHSFYDFIVT 280 KARGKSGPLF 290 NFDVHDDVRL 300 LSDATVEKDE 310 SHAGKVVLRS 320 WYEKNKHIFP 330 ASRWEPYDPE KKWDKYTIR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006397 mRNA processing
Biological Process GO:0043484 regulation of RNA splicing
Biological Process GO:0008380 RNA splicing
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.