Search Results

Overview

Uniprot IDQ14331
Protein NameProtein FRG1
Gene NameFRG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 YSYVKSTKLVLKGTK
15 KSTKLVLKGTKTKSK
212 CEINYVKKFQSFQDH
220 FQSFQDHKLKISKED
229 KISKEDSKILKKARK
236 KILKKARKDGFLHET

Function

Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B

Protein Sequence

10 MAEYSYVKST 20 KLVLKGTKTK 30 SKKKKSKDKK 40 RKREEDEETQ 50 LDIVGIWWTV 60 TNFGEISGTI 70 AIEMDKGTYI 80 HALDNGLFTL 90 GAPHKEVDEG 100 PSPPEQFTAV 110 KLSDSRIALK 120 SGYGKYLGIN 130 SDGLVVGRSD 140 AIGPREQWEP 150 VFQNGKMALL 160 ASNSCFIRCN 170 EAGDIEAKSK 180 TAGEEEMIKI 190 RSCAERETKK 200 KDDIPEEDKG 210 NVKQCEINYV 220 KKFQSFQDHK 230 LKISKEDSKI 240 LKKARKDGFL 250 HETLLDRRAK LKADRYCK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0007517 muscle organ development
Biological Process GO:0006364 rRNA processing
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0055120 striated muscle dense body
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0003723 RNA binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.