Overview
| Uniprot ID | Q14344 |
|---|
| Protein Name | Guanine nucleotide-binding protein subunit alpha-13 |
|---|
| Gene Name | GNA13 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 214 |
HEYDFEIKNVPFKMV |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16705036, PubMed:16787920, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation (PubMed:11976333). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche
Protein Sequence
10
MADFLPSRSV
20
LSVCFPGCLL
30
TSGEAEQQRK
40
SKEIDKCLSR
50
EKTYVKRLVK
60
ILLLGAGESG
70
KSTFLKQMRI
80
IHGQDFDQRA
90
REEFRPTIYS
100
NVIKGMRVLV
110
DAREKLHIPW
120
GDNSNQQHGD
130
KMMSFDTRAP
140
MAAQGMVETR
150
VFLQYLPAIR
160
ALWADSGIQN
170
AYDRRREFQL
180
GESVKYFLDN
190
LDKLGEPDYI
200
PSQQDILLAR
210
RPTKGIHEYD
220
FEIKNVPFKM
230
VDVGGQRSER
240
KRWFECFDSV
250
TSILFLVSSS
260
EFDQVLMEDR
270
LTNRLTESLN
280
IFETIVNNRV
290
FSNVSIILFL
300
NKTDLLEEKV
310
QIVSIKDYFL
320
EFEGDPHCLR
330
DVQKFLVECF
340
RNKRRDQQQK
350
PLYHHFTTAI
360
NTENIRLVFR
370
DVKDTILHDN
LKQLMLQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031526 |
brush border membrane |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005834 |
heterotrimeric G-protein complex |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098794 |
postsynapse |
| Molecular Function |
GO:0031752 |
D5 dopamine receptor binding |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0031683 |
G-protein beta/gamma-subunit complex binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0007188 |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0008217 |
regulation of blood pressure |
| Biological Process |
GO:0150052 |
regulation of postsynapse assembly |
| Biological Process |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
| Biological Process |
GO:0007266 |
Rho protein signal transduction |
| Biological Process |
GO:0160221 |
Rho-activating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.