Search Results
Overview
| Uniprot ID | Q14353 |
|---|---|
| Protein Name | Guanidinoacetate N-methyltransferase |
| Gene Name | GAMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | WAPRQTHKVIPLKGL |
Function
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:24415674, PubMed:26003046, PubMed:26319512). Important in nervous system development (PubMed:24415674)
Protein Sequence
10
MSAPSATPIF
20
APGENCSPAW
30
GAAPAAYDAA
40
DTHLRILGKP
50
VMERWETPYM
60
HALAAAASSK
70
GGRVLEVGFG
80
MAIAASKVQE
90
APIDEHWIIE
100
CNDGVFQRLR
110
DWAPRQTHKV
120
IPLKGLWEDV
130
APTLPDGHFD
140
GILYDTYPLS
150
EETWHTHQFN
160
FIKNHAFRLL
170
KPGGVLTYCN
180
LTSWGELMKS
190
KYSDITIMFE
200
ETQVPALLEA
210
GFRRENIRTE
220
VMALVPPADC
230
RYYAFPQMIT
PLVTKG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0030731 | guanidinoacetate N-methyltransferase activity |
| Molecular Function | GO:0008168 | methyltransferase activity |
| Biological Process | GO:0006601 | creatine biosynthetic process |
| Biological Process | GO:0006600 | creatine metabolic process |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0006936 | muscle contraction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.