Search Results

Overview

Uniprot ID	Q14376
Protein Name	UDP-glucose 4-epimerase
Gene Name	GALE
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
100	AVGESVQKPLDYYRV
259	IAALRKLKEQCGCRI

Function

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids

Protein Sequence

10 MAEKVLVTGG 20 AGYIGSHTVL 30 ELLEAGYLPV 40 VIDNFHNAFR 50 GGGSLPESLR 60 RVQELTGRSV 70 EFEEMDILDQ 80 GALQRLFKKY 90 SFMAVIHFAG 100 LKAVGESVQK 110 PLDYYRVNLT 120 GTIQLLEIMK 130 AHGVKNLVFS 140 SSATVYGNPQ 150 YLPLDEAHPT 160 GGCTNPYGKS 170 KFFIEEMIRD 180 LCQADKTWNA 190 VLLRYFNPTG 200 AHASGCIGED 210 PQGIPNNLMP 220 YVSQVAIGRR 230 EALNVFGNDY 240 DTEDGTGVRD 250 YIHVVDLAKG 260 HIAALRKLKE 270 QCGCRIYNLG 280 TGTGYSVLQM 290 VQAMEKASGK 300 KIPYKVVARR 310 EGDVAACYAN 320 PSLAQEELGW 330 TAALGLDRMC 340 EDLWRWQKQN PSGFGTQA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0003978	UDP-glucose 4-epimerase activity
Molecular Function	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity
Biological Process	GO:0019388	galactose catabolic process
Biological Process	GO:0033499	galactose catabolic process via UDP-galactose, Leloir pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.