Search Results
Overview
| Uniprot ID | Q14397 |
|---|---|
| Protein Name | Glucokinase regulatory protein |
| Gene Name | GCKR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 318 | PKIATLMKSVSTSLE |
Function
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961)
Protein Sequence
10
MPGTKRFQHV
20
IETPEPGKWE
30
LSGYEAAVPI
40
TEKSNPLTQD
50
LDKADAENIV
60
RLLGQCDAEI
70
FQEEGQALST
80
YQRLYSESIL
90
TTMVQVAGKV
100
QEVLKEPDGG
110
LVVLSGGGTS
120
GRMAFLMSVS
130
FNQLMKGLGQ
140
KPLYTYLIAG
150
GDRSVVASRE
160
GTEDSALHGI
170
EELKKVAAGK
180
KRVIVIGISV
190
GLSAPFVAGQ
200
MDCCMNNTAV
210
FLPVLVGFNP
220
VSMARNDPIE
230
DWSSTFRQVA
240
ERMQKMQEKQ
250
KAFVLNPAIG
260
PEGLSGSSRM
270
KGGSATKILL
280
ETLLLAAHKT
290
VDQGIAASQR
300
CLLEILRTFE
310
RAHQVTYSQS
320
PKIATLMKSV
330
STSLEKKGHV
340
YLVGWQTLGI
350
IAIMDGVECI
360
HTFGADFRDV
370
RGFLIGDHSD
380
MFNQKAELTN
390
QGPQFTFSQE
400
DFLTSILPSL
410
TEIDTVVFIF
420
TLDDNLTEVQ
430
TIVEQVKEKT
440
NHIQALAHST
450
VGQTLPIPLK
460
KLFPSIISIT
470
WPLLFFEYEG
480
NFIQKFQREL
490
STKWVLNTVS
500
TGAHVLLGKI
510
LQNHMLDLRI
520
SNSKLFWRAL
530
AMLQRFSGQS
540
KARCIESLLR
550
AIHFPQPLSD
560
DIRAAPISCH
570
VQVAHEKEQV
580
IPIALLSLLF
590
RCSITEAQAH
600
LAAAPSVCEA
610
VRSALAGPGQ
620
KRTADPLEIL
EPDVQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0070095 | fructose-6-phosphate binding |
| Molecular Function | GO:0141089 | glucose sensor activity |
| Molecular Function | GO:0019210 | kinase inhibitor activity |
| Biological Process | GO:1901135 | carbohydrate derivative metabolic process |
| Biological Process | GO:0001678 | intracellular glucose homeostasis |
| Biological Process | GO:0033132 | negative regulation of glucokinase activity |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0006110 | regulation of glycolytic process |
| Biological Process | GO:0009750 | response to fructose |
| Biological Process | GO:0009749 | response to glucose |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Biological Process | GO:0046415 | urate metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.