Overview
| Uniprot ID | Q14444 |
|---|
| Protein Name | Caprin-1 |
|---|
| Gene Name | CAPRIN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 223 |
DLLEGKEKPVCGTTY |
Function
mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633)
Protein Sequence
10
MPSATSHSGS
20
GSKSSGPPPP
30
SGSSGSEAAA
40
GAGAAAPASQ
50
HPATGTGAVQ
60
TEAMKQILGV
70
IDKKLRNLEK
80
KKGKLDDYQE
90
RMNKGERLNQ
100
DQLDAVSKYQ
110
EVTNNLEFAK
120
ELQRSFMALS
130
QDIQKTIKKT
140
ARREQLMREE
150
AEQKRLKTVL
160
ELQYVLDKLG
170
DDEVRTDLKQ
180
GLNGVPILSE
190
EELSLLDEFY
200
KLVDPERDMS
210
LRLNEQYEHA
220
SIHLWDLLEG
230
KEKPVCGTTY
240
KVLKEIVERV
250
FQSNYFDSTH
260
NHQNGLCEEE
270
EAASAPAVED
280
QVPEAEPEPA
290
EEYTEQSEVE
300
STEYVNRQFM
310
AETQFTSGEK
320
EQVDEWTVET
330
VEVVNSLQQQ
340
PQAASPSVPE
350
PHSLTPVAQA
360
DPLVRRQRVQ
370
DLMAQMQGPY
380
NFIQDSMLDF
390
ENQTLDPAIV
400
SAQPMNPTQN
410
MDMPQLVCPP
420
VHSESRLAQP
430
NQVPVQPEAT
440
QVPLVSSTSE
450
GYTASQPLYQ
460
PSHATEQRPQ
470
KEPIDQIQAT
480
ISLNTDQTTA
490
SSSLPAASQP
500
QVFQAGTSKP
510
LHSSGINVNA
520
APFQSMQTVF
530
NMNAPVPPVN
540
EPETLKQQNQ
550
YQASYNQSFS
560
SQPHQVEQTE
570
LQQEQLQTVV
580
GTYHGSPDQS
590
HQVTGNHQQP
600
PQQNTGFPRS
610
NQPYYNSRGV
620
SRGGSRGARG
630
LMNGYRGPAN
640
GFRGGYDGYR
650
PSFSNTPNSG
660
YTQSQFSAPR
670
DYSGYQRDGY
680
QQNFKRGSGQ
690
SGPRGAPRGR
700
GGPPRPNRGM
PQMNTQQVN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031252 |
cell leading edge |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043232 |
intracellular membraneless organelle |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:0140677 |
molecular function activator activity |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0035591 |
signaling adaptor activity |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0140694 |
membraneless organelle assembly |
| Biological Process |
GO:0017148 |
negative regulation of translation |
| Biological Process |
GO:0050775 |
positive regulation of dendrite morphogenesis |
| Biological Process |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
| Biological Process |
GO:0062029 |
positive regulation of stress granule assembly |
| Biological Process |
GO:0106288 |
regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.