Overview
| Uniprot ID | Q14493 |
|---|
| Protein Name | Histone RNA hairpin-binding protein |
|---|
| Gene Name | SLBP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 98 |
EMARYKRKLLINDFG |
Function
RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity)
Protein Sequence
10
MACRPRSPPR
20
HQSRCDGDAS
30
PPSPARWSLG
40
RKRRADGRRW
50
RPEDAEEAEH
60
RGAERRPESF
70
TTPEGPKPRS
80
RCSDWASAVE
90
EDEMRTRVNK
100
EMARYKRKLL
110
INDFGRERKS
120
SSGSSDSKES
130
MSTVPADFET
140
DESVLMRRQK
150
QINYGKNTIA
160
YDRYIKEVPR
170
HLRQPGIHPK
180
TPNKFKKYSR
190
RSWDQQIKLW
200
KVALHFWDPP
210
AEEGCDLQEI
220
HPVDLESAES
230
SSEPQTSSQD
240
DFDVYSGTPT
250
KVRHMDSQVE
260
DEFDLEACLT
270
EPLRDFSAMS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0071204 |
histone pre-mRNA 3'end processing complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Molecular Function |
GO:0071208 |
histone pre-mRNA DCP binding |
| Molecular Function |
GO:0071207 |
histone pre-mRNA stem-loop binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0002191 |
cap-dependent translational initiation |
| Biological Process |
GO:0006398 |
mRNA 3'-end processing by stem-loop binding and cleavage |
| Biological Process |
GO:0051028 |
mRNA transport |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.