Search Results
Overview
| Uniprot ID | Q14533 |
|---|---|
| Protein Name | Keratin, type II cuticular Hb1 |
| Gene Name | KRT81 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 319 | GETLRRTKEEINELN |
Function
Structural component of intermediate filaments in the hair cortex (PubMed:10504448, PubMed:9402962). Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft (PubMed:10504448, PubMed:9402962)
Protein Sequence
10
MTCGSGFGGR
20
AFSCISACGP
30
RPGRCCITAA
40
PYRGISCYRG
50
LTGGFGSHSV
60
CGGFRAGSCG
70
RSFGYRSGGV
80
CGPSPPCITT
90
VSVNESLLTP
100
LNLEIDPNAQ
110
CVKQEEKEQI
120
KSLNSRFAAF
130
IDKVRFLEQQ
140
NKLLETKLQF
150
YQNRECCQSN
160
LEPLFEGYIE
170
TLRREAECVE
180
ADSGRLASEL
190
NHVQEVLEGY
200
KKKYEEEVSL
210
RATAENEFVA
220
LKKDVDCAYL
230
RKSDLEANVE
240
ALIQEIDFLR
250
RLYEEEILIL
260
QSHISDTSVV
270
VKLDNSRDLN
280
MDCIIAEIKA
290
QYDDIVTRSR
300
AEAESWYRSK
310
CEEMKATVIR
320
HGETLRRTKE
330
EINELNRMIQ
340
RLTAEVENAK
350
CQNSKLEAAV
360
AQSEQQGEAA
370
LSDARCKLAE
380
LEGALQKAKQ
390
DMACLIREYQ
400
EVMNSKLGLD
410
IEIATYRRLL
420
EGEEQRLCEG
430
IGAVNVCVSS
440
SRGGVVCGDL
450
CVSGSRPVTG
460
SVCSAPCNGN
470
VAVSTGLCAP
480
CGQLNTTCGG
490
GSCGVGSCGI
500
SSLGVGSCGS
SCRKC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0045095 | keratin filament |
| Molecular Function | GO:0030280 | structural constituent of skin epidermis |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0031424 | keratinization |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.