Search Results

Overview

Uniprot IDQ14562
Protein NameATP-dependent RNA helicase DHX8
Gene NameDHX8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
547 KHAFGGNKASYGKKT

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946)

Protein Sequence

10 MAVAVAMAGA 20 LIGSEPGPAE 30 ELAKLEYLSL 40 VSKVCTELDN 50 HLGINDKDLA 60 EFVISLAEKN 70 TTFDTFKASL 80 VKNGAEFTDS 90 LISNLLRLIQ 100 TMRPPAKPST 110 SKDPVVKPKT 120 EKEKLKELFP 130 VLCQPDNPSV 140 RTMLDEDDVK 150 VAVDVLKELE 160 ALMPSAAGQE 170 KQRDAEHRDR 180 TKKKKRSRSR 190 DRNRDRDRDR 200 ERNRDRDHKR 210 RHRSRSRSRS 220 RTRERNKVKS 230 RYRSRSRSQS 240 PPKDRKDRDK 250 YGERNLDRWR 260 DKHVDRPPPE 270 EPTIGDIYNG 280 KVTSIMQFGC 290 FVQLEGLRKR 300 WEGLVHISEL 310 RREGRVANVA 320 DVVSKGQRVK 330 VKVLSFTGTK 340 TSLSMKDVDQ 350 ETGEDLNPNR 360 RRNLVGETNE 370 ETSMRNPDRP 380 THLSLVSAPE 390 VEDDSLERKR 400 LTRISDPEKW 410 EIKQMIAANV 420 LSKEEFPDFD 430 EETGILPKVD 440 DEEDEDLEIE 450 LVEEEPPFLR 460 GHTKQSMDMS 470 PIKIVKNPDG 480 SLSQAAMMQS 490 ALAKERRELK 500 QAQREAEMDS 510 IPMGLNKHWV 520 DPLPDAEGRQ 530 IAANMRGIGM 540 MPNDIPEWKK 550 HAFGGNKASY 560 GKKTQMSILE 570 QRESLPIYKL 580 KEQLVQAVHD 590 NQILIVIGET 600 GSGKTTQITQ 610 YLAEAGYTSR 620 GKIGCTQPRR 630 VAAMSVAKRV 640 SEEFGCCLGQ 650 EVGYTIRFED 660 CTSPETVIKY 670 MTDGMLLREC 680 LIDPDLTQYA 690 IIMLDEAHER 700 TIHTDVLFGL 710 LKKTVQKRQD 720 MKLIVTSATL 730 DAVKFSQYFY 740 EAPIFTIPGR 750 TYPVEILYTK 760 EPETDYLDAS 770 LITVMQIHLT 780 EPPGDILVFL 790 TGQEEIDTAC 800 EILYERMKSL 810 GPDVPELIIL 820 PVYSALPSEM 830 QTRIFDPAPP 840 GSRKVVIATN 850 IAETSLTIDG 860 IYYVVDPGFV 870 KQKVYNSKTG 880 IDQLVVTPIS 890 QAQAKQRAGR 900 AGRTGPGKCY 910 RLYTERAYRD 920 EMLTTNVPEI 930 QRTNLASTVL 940 SLKAMGINDL 950 LSFDFMDAPP 960 METLITAMEQ 970 LYTLGALDDE 980 GLLTRLGRRM 990 AEFPLEPMLC 1000 KMLIMSVHLG 1010 CSEEMLTIVS 1020 MLSVQNVFYR 1030 PKDKQALADQ 1040 KKAKFHQTEG 1050 DHLTLLAVYN 1060 SWKNNKFSNP 1070 WCYENFIQAR 1080 SLRRAQDIRK 1090 QMLGIMDRHK 1100 LDVVSCGKST 1110 VRVQKAICSG 1120 FFRNAAKKDP 1130 QEGYRTLIDQ 1140 QVVYIHPSSA 1150 LFNRQPEWVV 1160 YHELVLTTKE 1170 YMREVTTIDP 1180 RWLVEFAPAF 1190 FKVSDPTKLS 1200 KQKKQQRLEP 1210 LYNRYEEPNA 1220 WRISRAFRRR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008186 ATP-dependent activity, acting on RNA
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006396 RNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.