Overview
| Uniprot ID | Q14566 |
|---|
| Protein Name | DNA replication licensing factor MCM6 |
|---|
| Gene Name | MCM6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 241 |
ESAQAGDKCDFTGTL |
| 654 |
EAFRLLNKSIIRVET |
Function
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425)
Protein Sequence
10
MDLAAAAEPG
20
AGSQHLEVRD
30
EVAEKCQKLF
40
LDFLEEFQSS
50
DGEIKYLQLA
60
EELIRPERNT
70
LVVSFVDLEQ
80
FNQQLSTTIQ
90
EEFYRVYPYL
100
CRALKTFVKD
110
RKEIPLAKDF
120
YVAFQDLPTR
130
HKIRELTSSR
140
IGLLTRISGQ
150
VVRTHPVHPE
160
LVSGTFLCLD
170
CQTVIRDVEQ
180
QFKYTQPNIC
190
RNPVCANRRR
200
FLLDTNKSRF
210
VDFQKVRIQE
220
TQAELPRGSI
230
PRSLEVILRA
240
EAVESAQAGD
250
KCDFTGTLIV
260
VPDVSKLSTP
270
GARAETNSRV
280
SGVDGYETEG
290
IRGLRALGVR
300
DLSYRLVFLA
310
CCVAPTNPRF
320
GGKELRDEEQ
330
TAESIKNQMT
340
VKEWEKVFEM
350
SQDKNLYHNL
360
CTSLFPTIHG
370
NDEVKRGVLL
380
MLFGGVPKTT
390
GEGTSLRGDI
400
NVCIVGDPST
410
AKSQFLKHVE
420
EFSPRAVYTS
430
GKASSAAGLT
440
AAVVRDEESH
450
EFVIEAGALM
460
LADNGVCCID
470
EFDKMDVRDQ
480
VAIHEAMEQQ
490
TISITKAGVK
500
ATLNARTSIL
510
AAANPISGHY
520
DRSKSLKQNI
530
NLSAPIMSRF
540
DLFFILVDEC
550
NEVTDYAIAR
560
RIVDLHSRIE
570
ESIDRVYSLD
580
DIRRYLLFAR
590
QFKPKISKES
600
EDFIVEQYKH
610
LRQRDGSGVT
620
KSSWRITVRQ
630
LESMIRLSEA
640
MARMHCCDEV
650
QPKHVKEAFR
660
LLNKSIIRVE
670
TPDVNLDQEE
680
EIQMEVDEGA
690
GGINGHADSP
700
APVNGINGYN
710
EDINQESAPK
720
ASLRLGFSEY
730
CRISNLIVLH
740
LRKVEEEEDE
750
SALKRSELVN
760
WYLKEIESEI
770
DSEEELINKK
780
RIIEKVIHRL
790
THYDHVLIEL
800
TQAGLKGSTE
810
GSESYEEDPY
820
LVVNPNYLLE
D
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0071162 |
CMG complex |
| Cellular Component |
GO:0042555 |
MCM complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0003678 |
DNA helicase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003697 |
single-stranded DNA binding |
| Biological Process |
GO:0006260 |
DNA replication |
| Biological Process |
GO:0006270 |
DNA replication initiation |
| Biological Process |
GO:0000727 |
double-strand break repair via break-induced replication |
| Biological Process |
GO:1902969 |
mitotic DNA replication |
| Biological Process |
GO:0030174 |
regulation of DNA-templated DNA replication initiation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.