Search Results

Overview

Uniprot IDQ14571
Protein NameInositol 1,4,5-trisphosphate-gated calcium channel ITPR2
Gene NameITPR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1469 CNTTTDRKHADIFLE
1589 ARSGPRFKEALGGPA

Function

Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity)

Protein Sequence

10 MTEKMSSFLY 20 IGDIVSLYAE 30 GSVNGFISTL 40 GLVDDRCVVH 50 PEAGDLANPP 60 KKFRDCLFKV 70 CPMNRYSAQK 80 QYWKAKQAKQ 90 GNHTEAALLK 100 KLQHAAELEQ 110 KQNESENKKL 120 LGEIVKYSNV 130 IQLLHIKSNK 140 YLTVNKRLPA 150 LLEKNAMRVS 160 LDAAGNEGSW 170 FYIHPFWKLR 180 SEGDNIVVGD 190 KVVLMPVNAG 200 QPLHASNIEL 210 LDNPGCKEVN 220 AVNCNTSWKI 230 TLFMKYSSYR 240 EDVLKGGDVV 250 RLFHAEQEKF 260 LTCDEYEKKQ 270 HIFLRTTLRQ 280 SATSATSSKA 290 LWEIEVVHHD 300 PCRGGAGQWN 310 SLFRFKHLAT 320 GNYLAAELNP 330 DYRDAQNEGK 340 NVRDGVPPTS 350 KKKRQAGEKI 360 MYTLVSVPHG 370 NDIASLFELD 380 ATTLQRADCL 390 VPRNSYVRLR 400 HLCTNTWVTS 410 TSIPIDTDEE 420 RPVMLKIGTC 430 QTKEDKEAFA 440 IVSVPLSEVR 450 DLDFANDANK 460 VLATTVKKLE 470 NGTITQNERR 480 FVTKLLEDLI 490 FFVADVPNNG 500 QEVLDVVITK 510 PNRERQKLMR 520 EQNILAQVFG 530 ILKAPFKEKA 540 GEGSMLRLED 550 LGDQRYAPYK 560 YMLRLCYRVL 570 RHSQQDYRKN 580 QEYIAKNFCV 590 MQSQIGYDIL 600 AEDTITALLH 610 NNRKLLEKHI 620 TAKEIETFVS 630 LLRRNREPRF 640 LDYLSDLCVS 650 NTTAIPVTQE 660 LICKFMLSPG 670 NADILIQTKV 680 VSMQADNPME 690 SSILSDDIDD 700 EEVWLYWIDS 710 NKEPHGKAIR 720 HLAQEAKEGT 730 KADLEVLTYY 740 RYQLNLFARM 750 CLDRQYLAIN 760 QISTQLSVDL 770 ILRCVSDESL 780 PFDLRASFCR 790 LMLHMHVDRD 800 PQESVVPVRY 810 ARLWTEIPTK 820 ITIHEYDSIT 830 DSSRNDMKRK 840 FALTMEFVEE 850 YLKEVVNQPF 860 PFGDKEKNKL 870 TFEVVHLARN 880 LIYFGFYSFS 890 ELLRLTRTLL 900 AILDIVQAPM 910 SSYFERLSKF 920 QDGGNNVMRT 930 IHGVGEMMTQ 940 MVLSRGSIFP 950 MSVPDVPPSI 960 HPSKQGSPTE 970 HEDVTVMDTK 980 LKIIEILQFI 990 LSVRLDYRIS 1000 YMLSIYKKEF 1010 GEDNDNAETS 1020 ASGSPDTLLP 1030 SAIVPDIDEI 1040 AAQAETMFAG 1050 RKEKNPVQLD 1060 DEGGRTFLRV 1070 LIHLIMHDYP 1080 PLLSGALQLL 1090 FKHFSQRAEV 1100 LQAFKQVQLL 1110 VSNQDVDNYK 1120 QIKADLDQLR 1130 LTVEKSELWV 1140 EKSSNYENGE 1150 IGESQVKGGE 1160 EPIEESNILS 1170 PVQDGTKKPQ 1180 IDSNKSNNYR 1190 IVKEILIRLS 1200 KLCVQNKKCR 1210 NQHQRLLKNM 1220 GAHSVVLDLL 1230 QIPYEKNDEK 1240 MNEVMNLAHT 1250 FLQNFCRGNP 1260 QNQVLLHKHL 1270 NLFLTPGLLE 1280 AETMRHIFMN 1290 NYHLCNEISE 1300 RVVQHFVHCI 1310 ETHGRHVEYL 1320 RFLQTIVKAD 1330 GKYVKKCQDM 1340 VMTELINGGE 1350 DVLIFYNDRA 1360 SFPILLHMMC 1370 SERDRGDESG 1380 PLAYHITLVE 1390 LLAACTEGKN 1400 VYTEIKCNSL 1410 LPLDDIVRVV 1420 THDDCIPEVK 1430 IAYVNFVNHC 1440 YVDTEVEMKE 1450 IYTSNHIWKL 1460 FENFLVDMAR 1470 VCNTTTDRKH 1480 ADIFLEKCVT 1490 ESIMNIVSGF 1500 FNSPFSDNST 1510 SLQTHQPVFI 1520 QLLQSAFRIY 1530 NCTWPNPAQK 1540 ASVESCIRTL 1550 AEVAKNRGIA 1560 IPVDLDSQVN 1570 TLFMKSHSNM 1580 VQRAAMGWRL 1590 SARSGPRFKE 1600 ALGGPAWDYR 1610 NIIEKLQDVV 1620 ASLEHQFSPM 1630 MQAEFSVLVD 1640 VLYSPELLFP 1650 EGSDARIRCG 1660 AFMSKLINHT 1670 KKLMEKEEKL 1680 CIKILQTLRE 1690 MLEKKDSFVE 1700 EGNTLRKILL 1710 NRYFKGDYSI 1720 GVNGHLSGAY 1730 SKTAQVGGSF 1740 SGQDSDKMGI 1750 SMSDIQCLLD 1760 KEGASELVID 1770 VIVNTKNDRI 1780 FSEGIFLGIA 1790 LLEGGNTQTQ 1800 YSFYQQLHEQ 1810 KKSEKFFKVL 1820 YDRMKAAQKE 1830 IRSTVTVNTI 1840 DLGNKKRDDD 1850 NELMTSGPRM 1860 RVRDSTLHLK 1870 EGMKGQLTEA 1880 SSATSKAYCV 1890 YRREMDPEID 1900 IMCTGPEAGN 1910 TEEKSAEEVT 1920 MSPAIAIMQP 1930 ILRFLQLLCE 1940 NHNRELQNFL 1950 RNQNNKTNYN 1960 LVCETLQFLD 1970 CICGSTTGGL 1980 GLLGLYINEK 1990 NVALVNQNLE 2000 SLTEYCQGPC 2010 HENQTCIATH 2020 ESNGIDIIIA 2030 LILNDINPLG 2040 KYRMDLVLQL 2050 KNNASKLLLA 2060 IMESRHDSEN 2070 AERILFNMRP 2080 RELVDVMKNA 2090 YNQGLECDHG 2100 DDEGGDDGVS 2110 PKDVGHNIYI 2120 LAHQLARHNK 2130 LLQQMLKPGS 2140 DPDEGDEALK 2150 YYANHTAQIE 2160 IVRHDRTMEQ 2170 IVFPVPNICE 2180 YLTRESKCRV 2190 FNTTERDEQG 2200 SKVNDFFQQT 2210 EDLYNEMKWQ 2220 KKIRNNPALF 2230 WFSRHISLWG 2240 SISFNLAVFI 2250 NLAVALFYPF 2260 GDDGDEGTLS 2270 PLFSVLLWIA 2280 VAICTSMLFF 2290 FSKPVGIRPF 2300 LVSIMLRSIY 2310 TIGLGPTLIL 2320 LGAANLCNKI 2330 VFLVSFVGNR 2340 GTFTRGYRAV 2350 ILDMAFLYHV 2360 AYVLVCMLGL 2370 FVHEFFYSFL 2380 LFDLVYREET 2390 LLNVIKSVTR 2400 NGRSIILTAV 2410 LALILVYLFS 2420 IIGFLFLKDD 2430 FTMEVDRLKN 2440 RTPVTGSHQV 2450 PTMTLTTMME 2460 ACAKENCSPT 2470 IPASNTADEE 2480 YEDGIERTCD 2490 TLLMCIVTVL 2500 NQGLRNGGGV 2510 GDVLRRPSKD 2520 EPLFAARVVY 2530 DLLFYFIVII 2540 IVLNLIFGVI 2550 IDTFADLRSE 2560 KQKKEEILKT 2570 TCFICGLERD 2580 KFDNKTVSFE 2590 EHIKSEHNMW 2600 HYLYFIVLVK 2610 VKDPTEYTGP 2620 ESYVAQMIVE 2630 KNLDWFPRMR 2640 AMSLVSNEGD 2650 SEQNEIRSLQ 2660 EKLESTMSLV 2670 KQLSGQLAEL 2680 KEQMTEQRKN 2690 KQRLGFLGSN 2700 TPHVNHHMPP H

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031095 platelet dense tubular network membrane
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0030667 secretory granule membrane
Cellular Component GO:0030658 transport vesicle membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0015085 calcium ion transmembrane transporter activity
Molecular Function GO:0070679 inositol 1,4,5 trisphosphate binding
Molecular Function GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.