Search Results
Overview
| Uniprot ID | Q14571 |
|---|---|
| Protein Name | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 |
| Gene Name | ITPR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1469 | CNTTTDRKHADIFLE |
| 1589 | ARSGPRFKEALGGPA |
Function
Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity)
Protein Sequence
10
MTEKMSSFLY
20
IGDIVSLYAE
30
GSVNGFISTL
40
GLVDDRCVVH
50
PEAGDLANPP
60
KKFRDCLFKV
70
CPMNRYSAQK
80
QYWKAKQAKQ
90
GNHTEAALLK
100
KLQHAAELEQ
110
KQNESENKKL
120
LGEIVKYSNV
130
IQLLHIKSNK
140
YLTVNKRLPA
150
LLEKNAMRVS
160
LDAAGNEGSW
170
FYIHPFWKLR
180
SEGDNIVVGD
190
KVVLMPVNAG
200
QPLHASNIEL
210
LDNPGCKEVN
220
AVNCNTSWKI
230
TLFMKYSSYR
240
EDVLKGGDVV
250
RLFHAEQEKF
260
LTCDEYEKKQ
270
HIFLRTTLRQ
280
SATSATSSKA
290
LWEIEVVHHD
300
PCRGGAGQWN
310
SLFRFKHLAT
320
GNYLAAELNP
330
DYRDAQNEGK
340
NVRDGVPPTS
350
KKKRQAGEKI
360
MYTLVSVPHG
370
NDIASLFELD
380
ATTLQRADCL
390
VPRNSYVRLR
400
HLCTNTWVTS
410
TSIPIDTDEE
420
RPVMLKIGTC
430
QTKEDKEAFA
440
IVSVPLSEVR
450
DLDFANDANK
460
VLATTVKKLE
470
NGTITQNERR
480
FVTKLLEDLI
490
FFVADVPNNG
500
QEVLDVVITK
510
PNRERQKLMR
520
EQNILAQVFG
530
ILKAPFKEKA
540
GEGSMLRLED
550
LGDQRYAPYK
560
YMLRLCYRVL
570
RHSQQDYRKN
580
QEYIAKNFCV
590
MQSQIGYDIL
600
AEDTITALLH
610
NNRKLLEKHI
620
TAKEIETFVS
630
LLRRNREPRF
640
LDYLSDLCVS
650
NTTAIPVTQE
660
LICKFMLSPG
670
NADILIQTKV
680
VSMQADNPME
690
SSILSDDIDD
700
EEVWLYWIDS
710
NKEPHGKAIR
720
HLAQEAKEGT
730
KADLEVLTYY
740
RYQLNLFARM
750
CLDRQYLAIN
760
QISTQLSVDL
770
ILRCVSDESL
780
PFDLRASFCR
790
LMLHMHVDRD
800
PQESVVPVRY
810
ARLWTEIPTK
820
ITIHEYDSIT
830
DSSRNDMKRK
840
FALTMEFVEE
850
YLKEVVNQPF
860
PFGDKEKNKL
870
TFEVVHLARN
880
LIYFGFYSFS
890
ELLRLTRTLL
900
AILDIVQAPM
910
SSYFERLSKF
920
QDGGNNVMRT
930
IHGVGEMMTQ
940
MVLSRGSIFP
950
MSVPDVPPSI
960
HPSKQGSPTE
970
HEDVTVMDTK
980
LKIIEILQFI
990
LSVRLDYRIS
1000
YMLSIYKKEF
1010
GEDNDNAETS
1020
ASGSPDTLLP
1030
SAIVPDIDEI
1040
AAQAETMFAG
1050
RKEKNPVQLD
1060
DEGGRTFLRV
1070
LIHLIMHDYP
1080
PLLSGALQLL
1090
FKHFSQRAEV
1100
LQAFKQVQLL
1110
VSNQDVDNYK
1120
QIKADLDQLR
1130
LTVEKSELWV
1140
EKSSNYENGE
1150
IGESQVKGGE
1160
EPIEESNILS
1170
PVQDGTKKPQ
1180
IDSNKSNNYR
1190
IVKEILIRLS
1200
KLCVQNKKCR
1210
NQHQRLLKNM
1220
GAHSVVLDLL
1230
QIPYEKNDEK
1240
MNEVMNLAHT
1250
FLQNFCRGNP
1260
QNQVLLHKHL
1270
NLFLTPGLLE
1280
AETMRHIFMN
1290
NYHLCNEISE
1300
RVVQHFVHCI
1310
ETHGRHVEYL
1320
RFLQTIVKAD
1330
GKYVKKCQDM
1340
VMTELINGGE
1350
DVLIFYNDRA
1360
SFPILLHMMC
1370
SERDRGDESG
1380
PLAYHITLVE
1390
LLAACTEGKN
1400
VYTEIKCNSL
1410
LPLDDIVRVV
1420
THDDCIPEVK
1430
IAYVNFVNHC
1440
YVDTEVEMKE
1450
IYTSNHIWKL
1460
FENFLVDMAR
1470
VCNTTTDRKH
1480
ADIFLEKCVT
1490
ESIMNIVSGF
1500
FNSPFSDNST
1510
SLQTHQPVFI
1520
QLLQSAFRIY
1530
NCTWPNPAQK
1540
ASVESCIRTL
1550
AEVAKNRGIA
1560
IPVDLDSQVN
1570
TLFMKSHSNM
1580
VQRAAMGWRL
1590
SARSGPRFKE
1600
ALGGPAWDYR
1610
NIIEKLQDVV
1620
ASLEHQFSPM
1630
MQAEFSVLVD
1640
VLYSPELLFP
1650
EGSDARIRCG
1660
AFMSKLINHT
1670
KKLMEKEEKL
1680
CIKILQTLRE
1690
MLEKKDSFVE
1700
EGNTLRKILL
1710
NRYFKGDYSI
1720
GVNGHLSGAY
1730
SKTAQVGGSF
1740
SGQDSDKMGI
1750
SMSDIQCLLD
1760
KEGASELVID
1770
VIVNTKNDRI
1780
FSEGIFLGIA
1790
LLEGGNTQTQ
1800
YSFYQQLHEQ
1810
KKSEKFFKVL
1820
YDRMKAAQKE
1830
IRSTVTVNTI
1840
DLGNKKRDDD
1850
NELMTSGPRM
1860
RVRDSTLHLK
1870
EGMKGQLTEA
1880
SSATSKAYCV
1890
YRREMDPEID
1900
IMCTGPEAGN
1910
TEEKSAEEVT
1920
MSPAIAIMQP
1930
ILRFLQLLCE
1940
NHNRELQNFL
1950
RNQNNKTNYN
1960
LVCETLQFLD
1970
CICGSTTGGL
1980
GLLGLYINEK
1990
NVALVNQNLE
2000
SLTEYCQGPC
2010
HENQTCIATH
2020
ESNGIDIIIA
2030
LILNDINPLG
2040
KYRMDLVLQL
2050
KNNASKLLLA
2060
IMESRHDSEN
2070
AERILFNMRP
2080
RELVDVMKNA
2090
YNQGLECDHG
2100
DDEGGDDGVS
2110
PKDVGHNIYI
2120
LAHQLARHNK
2130
LLQQMLKPGS
2140
DPDEGDEALK
2150
YYANHTAQIE
2160
IVRHDRTMEQ
2170
IVFPVPNICE
2180
YLTRESKCRV
2190
FNTTERDEQG
2200
SKVNDFFQQT
2210
EDLYNEMKWQ
2220
KKIRNNPALF
2230
WFSRHISLWG
2240
SISFNLAVFI
2250
NLAVALFYPF
2260
GDDGDEGTLS
2270
PLFSVLLWIA
2280
VAICTSMLFF
2290
FSKPVGIRPF
2300
LVSIMLRSIY
2310
TIGLGPTLIL
2320
LGAANLCNKI
2330
VFLVSFVGNR
2340
GTFTRGYRAV
2350
ILDMAFLYHV
2360
AYVLVCMLGL
2370
FVHEFFYSFL
2380
LFDLVYREET
2390
LLNVIKSVTR
2400
NGRSIILTAV
2410
LALILVYLFS
2420
IIGFLFLKDD
2430
FTMEVDRLKN
2440
RTPVTGSHQV
2450
PTMTLTTMME
2460
ACAKENCSPT
2470
IPASNTADEE
2480
YEDGIERTCD
2490
TLLMCIVTVL
2500
NQGLRNGGGV
2510
GDVLRRPSKD
2520
EPLFAARVVY
2530
DLLFYFIVII
2540
IVLNLIFGVI
2550
IDTFADLRSE
2560
KQKKEEILKT
2570
TCFICGLERD
2580
KFDNKTVSFE
2590
EHIKSEHNMW
2600
HYLYFIVLVK
2610
VKDPTEYTGP
2620
ESYVAQMIVE
2630
KNLDWFPRMR
2640
AMSLVSNEGD
2650
SEQNEIRSLQ
2660
EKLESTMSLV
2670
KQLSGQLAEL
2680
KEQMTEQRKN
2690
KQRLGFLGSN
2700
TPHVNHHMPP
H
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031095 | platelet dense tubular network membrane |
| Cellular Component | GO:0043235 | receptor complex |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0030658 | transport vesicle membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0015085 | calcium ion transmembrane transporter activity |
| Molecular Function | GO:0070679 | inositol 1,4,5 trisphosphate binding |
| Molecular Function | GO:0005220 | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.