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Overview

Uniprot IDQ14596
Protein NameNext to BRCA1 gene 1 protein
Gene NameNBR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
539 ACIPQKAKNVASERE

Function

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133, PubMed:38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)

Protein Sequence

10 MEPQVTLNVT 20 FKNEIQSFLV 30 SDPENTTWAD 40 IEAMVKVSFD 50 LNTIQIKYLD 60 EENEEVSINS 70 QGEYEEALKM 80 AVKQGNQLQM 90 QVHEGHHVVD 100 EAPPPVVGAK 110 RLAARAGKKP 120 LAHYSSLVRV 130 LGSDMKTPED 140 PAVQSFPLVP 150 CDTDQPQDKP 160 PDWFTSYLET 170 FREQVVNETV 180 EKLEQKLHEK 190 LVLQNPSLGS 200 CPSEVSMPTS 210 EETLFLPENQ 220 FSWHIACNNC 230 QRRIVGVRYQ 240 CSLCPSYNIC 250 EDCEAGPYGH 260 DTNHVLLKLR 270 RPVVGSSEPF 280 CHSKYSTPRL 290 PAALEQVRLQ 300 KQVDKNFLKA 310 EKQRLRAEKK 320 QRKAEVKELK 330 KQLKLHRKIH 340 LWNSIHGLQS 350 PKSPLGRPES 360 LLQSNTLMLP 370 LQPCTSVMPM 380 LSAAFVDENL 390 PDGTHLQPGT 400 KFIKHWRMKN 410 TGNVKWSADT 420 KLKFMWGNLT 430 LASTEKKDVL 440 VPCLKAGHVG 450 VVSVEFIAPA 460 LEGTYTSHWR 470 LSHKGQQFGP 480 RVWCSIIVDP 490 FPSEESPDNI 500 EKGMISSSKT 510 DDLTCQQEET 520 FLLAKEERQL 530 GEVTEQTEGT 540 AACIPQKAKN 550 VASERELYIP 560 SVDLLTAQDL 570 LSFELLDINI 580 VQELERVPHN 590 TPVDVTPCMS 600 PLPHDSPLIE 610 KPGLGQIEEE 620 NEGAGFKALP 630 DSMVSVKRKA 640 ENIASVEEAE 650 EDLSGTQFVC 660 ETVIRSLTLD 670 AAPDHNPPCR 680 QKSLQMTFAL 690 PEGPLGNEKE 700 EIIHIAEEEA 710 VMEEEEDEED 720 EEEEDELKDE 730 VQSQSSASSE 740 DYIIILPECF 750 DTSRPLGDSM 760 YSSALSQPGL 770 ERGAEGKPGV 780 EAGQEPAEAG 790 ERLPGGENQP 800 QEHSISDILT 810 TSQTLETVPL 820 IPEVVELPPS 830 LPRSSPCVHH 840 HGSPGVDLPV 850 TIPEVSSVPD 860 QIRGEPRGSS 870 GLVNSRQKSY 880 DHSRHHHGSS 890 IAGGLVKGAL 900 SVAASAYKAL 910 FAGPPVTAQP 920 IISEDQTAAL 930 MAHLFEMGFC 940 DRQLNLRLLK 950 KHNYNILQVV 960 TELLQLNNND WYSQRY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005776 autophagosome
Biological Process GO:0030500 regulation of bone mineralization
Biological Process GO:0032872 regulation of stress-activated MAPK cascade
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005764 lysosome
Cellular Component GO:0031430 M band
Cellular Component GO:0016020 membrane
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0000407 phagophore assembly site
Cellular Component GO:0043235 receptor complex
Molecular Function GO:0051019 mitogen-activated protein kinase binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0016236 macroautophagy
Biological Process GO:0045668 negative regulation of osteoblast differentiation

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.