Search Results

Overview

Uniprot IDQ14624
Protein NameInter-alpha-trypsin inhibitor heavy chain H4
Gene NameITIH4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
111 QYSAAVAKGKSAGLV
119 GKSAGLVKATGRNME
98 YPGIIKEKAEAQAQY

Function

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration

Protein Sequence

10 MKPPRPVRTC 20 SKVLVLLSLL 30 AIHQTTTAEK 40 NGIDIYSLTV 50 DSRVSSRFAH 60 TVVTSRVVNR 70 ANTVQEATFQ 80 MELPKKAFIT 90 NFSMIIDGMT 100 YPGIIKEKAE 110 AQAQYSAAVA 120 KGKSAGLVKA 130 TGRNMEQFQV 140 SVSVAPNAKI 150 TFELVYEELL 160 KRRLGVYELL 170 LKVRPQQLVK 180 HLQMDIHIFE 190 PQGISFLETE 200 STFMTNQLVD 210 ALTTWQNKTK 220 AHIRFKPTLS 230 QQQKSPEQQE 240 TVLDGNLIIR 250 YDVDRAISGG 260 SIQIENGYFV 270 HYFAPEGLTT 280 MPKNVVFVID 290 KSGSMSGRKI 300 QQTREALIKI 310 LDDLSPRDQF 320 NLIVFSTEAT 330 QWRPSLVPAS 340 AENVNKARSF 350 AAGIQALGGT 360 NINDAMLMAV 370 QLLDSSNQEE 380 RLPEGSVSLI 390 ILLTDGDPTV 400 GETNPRSIQN 410 NVREAVSGRY 420 SLFCLGFGFD 430 VSYAFLEKLA 440 LDNGGLARRI 450 HEDSDSALQL 460 QDFYQEVANP 470 LLTAVTFEYP 480 SNAVEEVTQN 490 NFRLLFKGSE 500 MVVAGKLQDR 510 GPDVLTATVS 520 GKLPTQNITF 530 QTESSVAEQE 540 AEFQSPKYIF 550 HNFMERLWAY 560 LTIQQLLEQT 570 VSASDADQQA 580 LRNQALNLSL 590 AYSFVTPLTS 600 MVVTKPDDQE 610 QSQVAEKPME 620 GESRNRNVHS 630 GSTFFKYYLQ 640 GAKIPKPEAS 650 FSPRRGWNRQ 660 AGAAGSRMNF 670 RPGVLSSRQL 680 GLPGPPDVPD 690 HAAYHPFRRL 700 AILPASAPPA 710 TSNPDPAVSR 720 VMNMKIEETT 730 MTTQTPAPIQ 740 APSAILPLPG 750 QSVERLCVDP 760 RHRQGPVNLL 770 SDPEQGVEVT 780 GQYEREKAGF 790 SWIEVTFKNP 800 LVWVHASPEH 810 VVVTRNRRSS 820 AYKWKETLFS 830 VMPGLKMTMD 840 KTGLLLLSDP 850 DKVTIGLLFW 860 DGRGEGLRLL 870 LRDTDRFSSH 880 VGGTLGQFYQ 890 EVLWGSPAAS 900 DDGRRTLRVQ 910 GNDHSATRER 920 RLDYQEGPPG 930 VEISCWSVEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031089 platelet dense granule lumen
Molecular Function GO:0004866 endopeptidase inhibitor activity
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process
Biological Process GO:0034097 response to cytokine

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.