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Overview

Uniprot ID	Q14644
Protein Name	Ras GTPase-activating protein 3
Gene Name	RASA3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
184	RSEAKKTKVKRKTNN
186	EAKKTKVKRKTNNPQ

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor

Protein Sequence

10 MAVEDEGLRV 20 FQSVKIKIGE 30 AKNLPSYPGP 40 SKMRDCYCTV 50 NLDQEEVFRT 60 KIVEKSLCPF 70 YGEDFYCEIP 80 RSFRHLSFYI 90 FDRDVFRRDS 100 IIGKVAIQKE 110 DLQKYHNRDT 120 WFQLQHVDAD 130 SEVQGKVHLE 140 LRLSEVITDT 150 GVVCHKLATR 160 IVECQGLPIV 170 NGQCDPYATV 180 TLAGPFRSEA 190 KKTKVKRKTN 200 NPQFDEVFYF 210 EVTRPCSYSK 220 KSHFDFEEED 230 VDKLEIRVDL 240 WNASNLKFGD 250 EFLGELRIPL 260 KVLRQSSSYE 270 AWYFLQPRDN 280 GSKSLKPDDL 290 GSLRLNVVYT 300 EDHVFSSDYY 310 SPLRDLLLKS 320 ADVEPVSASA 330 AHILGEVCRE 340 KQEAAVPLVR 350 LFLHYGRVVP 360 FISAIASAEV 370 KRTQDPNTIF 380 RGNSLASKCI 390 DETMKLAGMH 400 YLHVTLKPAI 410 EEICQSHKPC 420 EIDPVKLKDG 430 ENLENNMENL 440 RQYVDRVFHA 450 ITESGVSCPT 460 VMCDIFFSLR 470 EAAAKRFQDD 480 PDVRYTAVSS 490 FIFLRFFAPA 500 ILSPNLFQLT 510 PHHTDPQTSR 520 TLTLISKTVQ 530 TLGSLSKSKS 540 ASFKESYMAT 550 FYEFFNEQKY 560 ADAVKNFLDL 570 ISSSGRRDPK 580 SVEQPIVLKE 590 GFMIKRAQGR 600 KRFGMKNFKK 610 RWFRLTNHEF 620 TYHKSKGDQP 630 LYSIPIENIL 640 AVEKLEEESF 650 KMKNMFQVIQ 660 PERALYIQAN 670 NCVEAKDWID 680 ILTKVSQCNQ 690 KRLTVYHPSA 700 YLSGHWLCCR 710 APSDSAPGCS 720 PCTGGLPANI 730 QLDIDGDRET 740 ERIYSLFNLY 750 MSKLEKMQEA 760 CGSKSVYDGP 770 EQEEYSTFVI 780 DDPQETYKTL 790 KQVIAGVGAL 800 EQEHAQYKRD 810 KFKKTKYGSQ 820 EHPIGDKSFQ 830 NYIRQQSETS THSI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005246	calcium channel regulator activity
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction
Biological Process	GO:0030168	platelet activation
Biological Process	GO:1902531	regulation of intracellular signal transduction
Biological Process	GO:0007165	signal transduction

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.