Search Results
Overview
| Uniprot ID | Q14651 |
|---|---|
| Protein Name | Plastin-1 |
| Gene Name | PLS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | LENDPDCKHLIPMNP |
| 380 | NTYPCLHKPNNNDID |
| 457 | ALGGNMKKIENCNYA |
Function
Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions
Protein Sequence
10
MENSTTTISR
20
EELEELQEAF
30
NKIDIDNSGY
40
VSDYELQDLF
50
KEASLPLPGY
60
KVREIVEKIL
70
SVADSNKDGK
80
ISFEEFVSLM
90
QELKSKDISK
100
TFRKIINKRE
110
GITAIGGTST
120
ISSEGTQHSY
130
SEEEKVAFVN
140
WINKALENDP
150
DCKHLIPMNP
160
NDDSLFKSLA
170
DGILLCKMIN
180
LSEPDTIDER
190
AINKKKLTPF
200
TISENLNLAL
210
NSASAIGCTV
220
VNIGASDLKE
230
GKPHLVLGLL
240
WQIIKVGLFA
250
DIEISRNEAL
260
IALLNEGEEL
270
EELMKLSPEE
280
LLLRWVNYHL
290
TNAGWHTISN
300
FSQDIKDSRA
310
YFHLLNQIAP
320
KGGEDGPAIA
330
IDLSGINETN
340
DLKRAGLMLQ
350
EADKLGCKQF
360
VTPADVVSGN
370
PKLNLAFVAN
380
LFNTYPCLHK
390
PNNNDIDMNL
400
LEGESKEERT
410
FRNWMNSLGV
420
NPYINHLYSD
430
LADALVIFQL
440
YEMIRVPVNW
450
SHVNKPPYPA
460
LGGNMKKIEN
470
CNYAVELGKN
480
KAKFSLVGIA
490
GQDLNEGNST
500
LTLALVWQLM
510
RRYTLNVLSD
520
LGEGEKVNDE
530
IIIKWVNQTL
540
KSANKKTSIS
550
SFKDKSISTS
560
LPVLDLIDAI
570
APNAVRQEMI
580
RRENLSDEDK
590
LNNAKYAISV
600
ARKIGARIYA
610
LPDDLVEVKP
620
KMVMTVFACL
MGKGLNRIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0032432 | actin filament bundle |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0032420 | stereocilium |
| Cellular Component | GO:1990357 | terminal web |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0051639 | actin filament network formation |
| Biological Process | GO:0060088 | auditory receptor cell stereocilium organization |
| Biological Process | GO:0001951 | intestinal D-glucose absorption |
| Biological Process | GO:0040018 | positive regulation of multicellular organism growth |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0032532 | regulation of microvillus length |
| Biological Process | GO:0060121 | vestibular receptor cell stereocilium organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.