Search Results

Overview

Uniprot IDQ14677
Protein NameClathrin interactor 1
Gene NameCLINT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 KVRELVDKATNVVMN
156 RKKAKKNKDKYVGVS
158 KAKKNKDKYVGVSSD
183 YDPEPKSKWDEEWDK
200 SAFPFSDKLGELSDK
218 TIDDTISKFRRKDRE
247 ARRGRSPKGEFKDEE
283 KRTANPSKTIDLGAA

Function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly

Protein Sequence

10 MLNMWKVREL 20 VDKATNVVMN 30 YSEIESKVRE 40 ATNDDPWGPS 50 GQLMGEIAKA 60 TFMYEQFPEL 70 MNMLWSRMLK 80 DNKKNWRRVY 90 KSLLLLAYLI 100 RNGSERVVTS 110 AREHIYDLRS 120 LENYHFVDEH 130 GKDQGINIRQ 140 KVKELVEFAQ 150 DDDRLREERK 160 KAKKNKDKYV 170 GVSSDSVGGF 180 RYSERYDPEP 190 KSKWDEEWDK 200 NKSAFPFSDK 210 LGELSDKIGS 220 TIDDTISKFR 230 RKDREDSPER 240 CSDSDEEKKA 250 RRGRSPKGEF 260 KDEEETVTTK 270 HIHITQATET 280 TTTRHKRTAN 290 PSKTIDLGAA 300 AHYTGDKASP 310 DQNASTHTPQ 320 SSVKTSVPSS 330 KSSGDLVDLF 340 DGTSQSTGGS 350 ADLFGGFADF 360 GSAAASGSFP 370 SQVTATSGNG 380 DFGDWSAFNQ 390 APSGPVASSG 400 EFFGSASQPA 410 VELVSGSQSA 420 LGPPPAASNS 430 SDLFDLMGSS 440 QATMTSSQSM 450 NFSMMSTNTV 460 GLGLPMSRSQ 470 NTDMVQKSVS 480 KTLPSTWSDP 490 SVNISLDNLL 500 PGMQPSKPQQ 510 PSLNTMIQQQ 520 NMQQPMNVMT 530 QSFGAVNLSS 540 PSNMLPVRPQ 550 TNALIGGPMP 560 MSMPNVMTGT 570 MGMAPLGNTP 580 MMNQSMMGMN 590 MNIGMSAAGM 600 GLTGTMGMGM 610 PNIAMTSGTV 620 QPKQDAFANF ANFSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030125 clathrin vesicle coat
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0030276 clathrin binding
Molecular Function GO:0005543 phospholipid binding
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0006897 endocytosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.