Search Results

Overview

Uniprot ID	Q14683
Protein Name	Structural maintenance of chromosomes protein 1A
Gene Name	SMC1A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1030	PNMKAMEKLESVRDK
1037	KLESVRDKFQETSDE
190	QFNYHRKKNIAAERK
660	SGGASDLKAKARRWD
903	KKLGGANKEMTHLQK

Function

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint

Protein Sequence

10 MGFLKLIEIE 20 NFKSYKGRQI 30 IGPFQRFTAI 40 IGPNGSGKSN 50 LMDAISFVLG 60 EKTSNLRVKT 70 LRDLIHGAPV 80 GKPAANRAFV 90 SMVYSEEGAE 100 DRTFARVIVG 110 GSSEYKINNK 120 VVQLHEYSEE 130 LEKLGILIKA 140 RNFLVFQGAV 150 ESIAMKNPKE 160 RTALFEEISR 170 SGELAQEYDK 180 RKKEMVKAEE 190 DTQFNYHRKK 200 NIAAERKEAK 210 QEKEEADRYQ 220 RLKDEVVRAQ 230 VQLQLFKLYH 240 NEVEIEKLNK 250 ELASKNKEIE 260 KDKKRMDKVE 270 DELKEKKKEL 280 GKMMREQQQI 290 EKEIKEKDSE 300 LNQKRPQYIK 310 AKENTSHKIK 320 KLEAAKKSLQ 330 NAQKHYKKRK 340 GDMDELEKEM 350 LSVEKARQEF 360 EERMEEESQS 370 QGRDLTLEEN 380 QVKKYHRLKE 390 EASKRAATLA 400 QELEKFNRDQ 410 KADQDRLDLE 420 ERKKVETEAK 430 IKQKLREIEE 440 NQKRIEKLEE 450 YITTSKQSLE 460 EQKKLEGELT 470 EEVEMAKRRI 480 DEINKELNQV 490 MEQLGDARID 500 RQESSRQQRK 510 AEIMESIKRL 520 YPGSVYGRLI 530 DLCQPTQKKY 540 QIAVTKVLGK 550 NMDAIIVDSE 560 KTGRDCIQYI 570 KEQRGEPETF 580 LPLDYLEVKP 590 TDEKLRELKG 600 AKLVIDVIRY 610 EPPHIKKALQ 620 YACGNALVCD 630 NVEDARRIAF 640 GGHQRHKTVA 650 LDGTLFQKSG 660 VISGGASDLK 670 AKARRWDEKA 680 VDKLKEKKER 690 LTEELKEQMK 700 AKRKEAELRQ 710 VQSQAHGLQM 720 RLKYSQSDLE 730 QTKTRHLALN 740 LQEKSKLESE 750 LANFGPRIND 760 IKRIIQSRER 770 EMKDLKEKMN 780 QVEDEVFEEF 790 CREIGVRNIR 800 EFEEEKVKRQ 810 NEIAKKRLEF 820 ENQKTRLGIQ 830 LDFEKNQLKE 840 DQDKVHMWEQ 850 TVKKDENEIE 860 KLKKEEQRHM 870 KIIDETMAQL 880 QDLKNQHLAK 890 KSEVNDKNHE 900 MEEIRKKLGG 910 ANKEMTHLQK 920 EVTAIETKLE 930 QKRSDRHNLL 940 QACKMQDIKL 950 PLSKGTMDDI 960 SQEEGSSQGE 970 DSVSGSQRIS 980 SIYAREALIE 990 IDYGDLCEDL 1000 KDAQAEEEIK 1010 QEMNTLQQKL 1020 NEQQSVLQRI 1030 AAPNMKAMEK 1040 LESVRDKFQE 1050 TSDEFEAARK 1060 RAKKAKQAFE 1070 QIKKERFDRF 1080 NACFESVATN 1090 IDEIYKALSR 1100 NSSAQAFLGP 1110 ENPEEPYLDG 1120 INYNCVAPGK 1130 RFRPMDNLSG 1140 GEKTVAALAL 1150 LFAIHSYKPA 1160 PFFVLDEIDA 1170 ALDNTNIGKV 1180 ANYIKEQSTC 1190 NFQAIVISLK 1200 EEFYTKAESL 1210 IGVYPEQGDC 1220 VISKVLTFDL 1230 TKYPDANPNP NEQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0008278	cohesin complex
Cellular Component	GO:0000794	condensed nuclear chromosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0030893	meiotic cohesin complex
Cellular Component	GO:0097431	mitotic spindle pole
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0036033	mediator complex binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0034087	establishment of mitotic sister chromatid cohesion
Biological Process	GO:0051321	meiotic cell cycle
Biological Process	GO:0007064	mitotic sister chromatid cohesion
Biological Process	GO:0000070	mitotic sister chromatid segregation
Biological Process	GO:0090307	mitotic spindle assembly
Biological Process	GO:0072423	response to DNA damage checkpoint signaling
Biological Process	GO:0009314	response to radiation
Biological Process	GO:0007062	sister chromatid cohesion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.