Search Results

Overview

Uniprot ID	Q14686
Protein Name	Nuclear receptor coactivator 6
Gene Name	NCOA6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1822	KGKGKVDKIGQILLT
1830	IGQILLTKACKKVTG
1834	LLTKACKKVTGSLEK
2009	EPKEIVEKSKIPGRR
2049	ASASSSTKDITSAVQ
2058	ITSAVQSKRRKSK**

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins

Protein Sequence

10 MVLDDLPNLE 20 DIYTSLCSST 30 MEDSEMDFDS 40 GLEDDDTKSD 50 SILEDSTIFV 60 AFKGNIDDKD 70 FKWKLDAILK 80 NVPNLLHMES 90 SKLKVQKVEP 100 WNSVRVTFNI 110 PREAAERLRI 120 LAQSNNQQLR 130 DLGILSVQIE 140 GEGAINLALA 150 QNRSQDVRMN 160 GPMGAGNSVR 170 MEAGFPMASG 180 PGIIRMNNPA 190 TVMIPPGGNV 200 SSSMMAPGPN 210 PELQPRTPRP 220 ASQSDAMDPL 230 LSGLHIQQQS 240 HPSGSLAPPH 250 HPMQPVSVNR 260 QMNPANFPQL 270 QQQQQQQQQQ 280 QQQQQQQQQQ 290 QQQQQLQARP 300 PQQHQQQQPQ 310 GIRPQFTAPT 320 QVPVPPGWNQ 330 LPSGALQPPP 340 AQGSLGTMTA 350 NQGWKKAPLP 360 GPMQQQLQAR 370 PSLATVQTPS 380 HPPPPYPFGS 390 QQASQAHTNF 400 PQMSNPGQFT 410 APQMKSLQGG 420 PSRVPTPLQQ 430 PHLTNKSPAS 440 SPSSFQQGSP 450 ASSPTVNQTQ 460 QQMGPRPPQN 470 NPLPQGFQQP 480 VSSPGRNPMV 490 QQGNVPPNFM 500 VMQQQPPNQG 510 PQSLHPGLGG 520 MPKRLPPGFS 530 AGQANPNFMQ 540 GQVPSTTATT 550 PGNSGAPQLQ 560 ANQNVQHAGG 570 QGAGPPQNQM 580 QVSHGPPNMM 590 QPSLMGIHGN 600 MNNQQAGTSG 610 VPQVNLSNMQ 620 GQPQQGPPSQ 630 LMGMHQQIVP 640 SQGQMVQQQG 650 TLNPQNPMIL 660 SRAQLMPQGQ 670 MMVNPPSQNL 680 GPSPQRMTPP 690 KQMLSQQGPQ 700 MMAPHNQMMG 710 PQGQVLLQQN 720 PMIEQIMTNQ 730 MQGNKQQFNT 740 QNQSNVMPGP 750 AQIMRGPTPN 760 MQGNMVQFTG 770 QMSGQMLPQQ 780 GPVNNSPSQV 790 MGIQGQVLRP 800 PGPSPHMAQQ 810 HGDPATTANN 820 DVSLSQMMPD 830 VSIQQTNMVP 840 PHVQAMQGNS 850 ASGNHFSGHG 860 MSFNAPFSGA 870 PNGNQMSCGQ 880 NPGFPVNKDV 890 TLTSPLLVNL 900 LQSDISAGHF 910 GVNNKQNNTN 920 ANKPKKKKPP 930 RKKKNSQQDL 940 NTPDTRPAGL 950 EEADQPPLPG 960 EQGINLDNSG 970 PKLPEFSNRP 980 PGYPSQPVEQ 990 RPLQQMPPQL 1000 MQHVAPPPQP 1010 PQQQPQPQLP 1020 QQQQPPPPSQ 1030 PQSQQQQQQQ 1040 QQMMMMLMMQ 1050 QDPKSVRLPV 1060 SQNVHPPRGP 1070 LNPDSQRMPM 1080 QQSGSVPVMV 1090 SLQGPASVPP 1100 SPDKQRMPMP 1110 VNTPLGSNSR 1120 KMVYQESPQN 1130 PSSSPLAEMA 1140 SLPEASGSEA 1150 PSVPGGPNNM 1160 PSHVVLPQNQ 1170 LMMTGPKPGP 1180 SPLSATQGAT 1190 PQQPPVNSLP 1200 SSHGHHFPNV 1210 AAPTQTSRPK 1220 TPNRASPRPY 1230 YPQTPNNRPP 1240 STEPSEISLS 1250 PERLNASIAG 1260 LFPPQINIPL 1270 PPRPNLNRGF 1280 DQQGLNPTTL 1290 KAIGQAPSNL 1300 TMNPSNFATP 1310 QTHKLDSVVV 1320 NSGKQSNSGA 1330 TKRASPSNSR 1340 RSSPGSSRKT 1350 TPSPGRQNSK 1360 APKLTLASQT 1370 NAALLQNVEL 1380 PRNVLVSPTP 1390 LANPPVPGSF 1400 PNNSGLNPQN 1410 STVSVAAVGG 1420 VVEDNKESLN 1430 VPQDSDCQNS 1440 QSRKEQVNIE 1450 LKAVPAQEVK 1460 MVVPEDQSKK 1470 DGQPSDPNKL 1480 PSVEENKNLV 1490 SPAMREAPTS 1500 LSQLLDNSGA 1510 PNVTIKPPGL 1520 TDLEVTPPVV 1530 SGEDLKKASV 1540 IPTLQDLSSS 1550 KEPSNSLNLP 1560 HSNELCSSLV 1570 HPELSEVSSN 1580 VAPSIPPVMS 1590 RPVSSSSIST 1600 PLPPNQITVF 1610 VTSNPITTSA 1620 NTSAALPTHL 1630 QSALMSTVVT 1640 MPNAGSKVMV 1650 SEGQSAAQSN 1660 ARPQFITPVF 1670 INSSSIIQVM 1680 KGSQPSTIPA 1690 APLTTNSGLM 1700 PPSVAVVGPL 1710 HIPQNIKFSS 1720 APVPPNALSS 1730 SPAPNIQTGR 1740 PLVLSSRATP 1750 VQLPSPPCTS 1760 SPVVPSHPPV 1770 QQVKELNPDE 1780 ASPQVNTSAD 1790 QNTLPSSQST 1800 TMVSPLLTNS 1810 PGSSGNRRSP 1820 VSSSKGKGKV 1830 DKIGQILLTK 1840 ACKKVTGSLE 1850 KGEEQYGADG 1860 ETEGQGLDTT 1870 APGLMGTEQL 1880 STELDSKTPT 1890 PPAPTLLKMT 1900 SSPVGPGTAS 1910 AGPSLPGGAL 1920 PTSVRSIVTT 1930 LVPSELISAV 1940 PTTKSNHGGI 1950 ASESLAGGLV 1960 EEKVGSHPEL 1970 LPSIAPSQNL 1980 VSKETSTTAL 1990 QASVARPELE 2000 VNAAIVSGQS 2010 SEPKEIVEKS 2020 KIPGRRNSRT 2030 EEPTVASESV 2040 ENGHRKRSSR 2050 PASASSSTKD 2060 ITSAVQSKRR KSK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035097	histone methyltransferase complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005667	transcription regulator complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0030331	nuclear estrogen receptor binding
Molecular Function	GO:0046965	nuclear retinoid X receptor binding
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0007420	brain development
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006352	DNA-templated transcription initiation
Biological Process	GO:0007507	heart development
Biological Process	GO:0030099	myeloid cell differentiation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0009725	response to hormone

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.