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Overview

Uniprot IDQ14692
Protein NameRibosome biogenesis protein BMS1 homolog
Gene NameBMS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1172 HIPKALQKALPFKNK
43 DARKRNPKAFAVQSA
565 SDRVNLEKSLLMKKA
674 WKEDLSRKAAEAFLR
857 DLKGEMQKQAQLNRA

Function

GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus

Protein Sequence

10 MEAKDQKKHR 20 KKNSGPKAAK 30 KKKRLLQDLQ 40 LGDEEDARKR 50 NPKAFAVQSA 60 VRMARSFHRT 70 QDLKTKKHHI 80 PVVDRTPLEP 90 PPIVVVVMGP 100 PKVGKSTLIQ 110 CLIRNFTRQK 120 LTEIRGPVTI 130 VSGKKRRLTI 140 IECGCDINMM 150 IDLAKVADLV 160 LMLIDASFGF 170 EMETFEFLNI 180 CQVHGFPKIM 190 GVLTHLDSFK 200 HNKQLKKTKK 210 RLKHRFWTEV 220 YPGAKLFYLS 230 GMVHGEYQNQ 240 EIHNLGRFIT 250 VMKFRPLTWQ 260 TSHPYILADR 270 MEDLTNPEDI 280 RTNIKCDRKV 290 SLYGYLRGAH 300 LKNKSQIHMP 310 GVGDFAVSDI 320 SFLPDPCALP 330 EQQKKRCLNE 340 KEKLVYAPLS 350 GVGGVLYDKD 360 AVYVDLGGSH 370 VFQDEVGPTH 380 ELVQSLISTH 390 STIDAKMASS 400 RVTLFSDSKP 410 LGSEDIDNQG 420 LMMPKEEKQM 430 DLNTGRMRRK 440 AIFGDEDESG 450 DSDDEEDDEM 460 SEDDGLENGS 470 SDEEAEEEEN 480 AEMTDQYMAV 490 KGIKRRKLEL 500 EEDSEMDLPA 510 FADSDDDLER 520 SSAEEGEAEE 530 ADESSEEEDC 540 TAGEKGISGS 550 KAAGEGSKAG 560 LSPANCQSDR 570 VNLEKSLLMK 580 KAALPTFDSG 590 HCTAEEVFAS 600 EDESEESSSL 610 SAEEEDSENE 620 EAIRKKLSKP 630 SQVSSGQKLG 640 PQNFIDETSD 650 IENLLKEEED 660 YKEENNDSKE 670 TSGALKWKED 680 LSRKAAEAFL 690 RQQQAAPNLR 700 KLIYGTVTED 710 NEEEDDDTLE 720 ELGGLFRVNQ 730 PDRECKHKAD 740 SLDCSRFLVE 750 APHDWDLEEV 760 MNSIRDCFVT 770 GKWEDDKDAA 780 KVLAEDEELY 790 GDFEDLETGD 800 VHKGKSGPNT 810 QNEDIEKEVK 820 EEIDPDEEES 830 AKKKHLDKKR 840 KLKEMFDAEY 850 DEGESTYFDD 860 LKGEMQKQAQ 870 LNRAEFEDQD 880 DEARVQYEGF 890 RPGMYVRIEI 900 ENVPCEFVQN 910 FDPHYPIILG 920 GLGNSEGNVG 930 YVQMRLKKHR 940 WYKKILKSRD 950 PIIFSVGWRR 960 FQTIPLYYIE 970 DHNGRQRLLK 980 YTPQHMHCGA 990 AFWGPITPQG 1000 TGFLAIQSVS 1010 GIMPDFRIAA 1020 TGVVLDLDKS 1030 IKIVKKLKLT 1040 GFPYKIFKNT 1050 SFIKGMFNSA 1060 LEVAKFEGAV 1070 IRTVSGIRGQ 1080 IKKALRAPEG 1090 AFRASFEDKL 1100 LMSDIVFMRT 1110 WYPVSIPAFY 1120 NPVTSLLKPV 1130 GEKDTWSGMR 1140 TTGQLRLAHG 1150 VRLKANKDSL 1160 YKPILRQKKH 1170 FNSLHIPKAL 1180 QKALPFKNKP 1190 KTQAKAGKVP 1200 KDRRRPAVIR 1210 EPHERKILAL 1220 LDALSTVHSQ 1230 KMKKAKEQRH 1240 LHNKEHFRAK 1250 QKEEEEKLKR 1260 QKDLRKKLFR 1270 IQGQKERRNQ 1280 KSSLKGAEGQ LQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030686 90S preribosome
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.