Search Results

Overview

Uniprot IDQ14697
Protein NameNeutral alpha-glucosidase AB
Gene NameGANAB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
269 HADNLRLKVTEGGEP
462 RLASKRRKLVAIVDP
48 CEESSFCKRQRSIRP
491 RNLGLYVKTRDGSDY
899 VVIIGAGKPAAVVLQ
908 AAVVLQTKGSPESRL
930 TSVLVLRKPGINVAS

Function

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053)

Protein Sequence

10 MAAVAAVAAR 20 RRRSWASLVL 30 AFLGVCLGIT 40 LAVDRSNFKT 50 CEESSFCKRQ 60 RSIRPGLSPY 70 RALLDSLQLG 80 PDSLTVHLIH 90 EVTKVLLVLE 100 LQGLQKNMTR 110 FRIDELEPRR 120 PRYRVPDVLV 130 ADPPIARLSV 140 SGRDENSVEL 150 TMAEGPYKII 160 LTARPFRLDL 170 LEDRSLLLSV 180 NARGLLEFEH 190 QRAPRVSQGS 200 KDPAEGDGAQ 210 PEETPRDGDK 220 PEETQGKAEK 230 DEPGAWEETF 240 KTHSDSKPYG 250 PMSVGLDFSL 260 PGMEHVYGIP 270 EHADNLRLKV 280 TEGGEPYRLY 290 NLDVFQYELY 300 NPMALYGSVP 310 VLLAHNPHRD 320 LGIFWLNAAE 330 TWVDISSNTA 340 GKTLFGKMMD 350 YLQGSGETPQ 360 TDVRWMSETG 370 IIDVFLLLGP 380 SISDVFRQYA 390 SLTGTQALPP 400 LFSLGYHQSR 410 WNYRDEADVL 420 EVDQGFDDHN 430 LPCDVIWLDI 440 EHADGKRYFT 450 WDPSRFPQPR 460 TMLERLASKR 470 RKLVAIVDPH 480 IKVDSGYRVH 490 EELRNLGLYV 500 KTRDGSDYEG 510 WCWPGSAGYP 520 DFTNPTMRAW 530 WANMFSYDNY 540 EGSAPNLFVW 550 NDMNEPSVFN 560 GPEVTMLKDA 570 QHYGGWEHRD 580 VHNIYGLYVH 590 MATADGLRQR 600 SGGMERPFVL 610 ARAFFAGSQR 620 FGAVWTGDNT 630 AEWDHLKISI 640 PMCLSLGLVG 650 LSFCGADVGG 660 FFKNPEPELL 670 VRWYQMGAYQ 680 PFFRAHAHLD 690 TGRREPWLLP 700 SQHNDIIRDA 710 LGQRYSLLPF 720 WYTLLYQAHR 730 EGIPVMRPLW 740 VQYPQDVTTF 750 NIDDQYLLGD 760 ALLVHPVSDS 770 GAHGVQVYLP 780 GQGEVWYDIQ 790 SYQKHHGPQT 800 LYLPVTLSSI 810 PVFQRGGTIV 820 PRWMRVRRSS 830 ECMKDDPITL 840 FVALSPQGTA 850 QGELFLDDGH 860 TFNYQTRQEF 870 LLRRFSFSGN 880 TLVSSSADPE 890 GHFETPIWIE 900 RVVIIGAGKP 910 AAVVLQTKGS 920 PESRLSFQHD 930 PETSVLVLRK 940 PGINVASDWS IHLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0017177 glucosidase II complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0090599 alpha-glucosidase activity
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Molecular Function GO:0033919 glucan 1,3-alpha-glucosidase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006491 N-glycan processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.