Search Results

Overview

Uniprot IDQ14738
Protein NameSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Gene NamePPP2R5D
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
268 ILHRIYGKFLGLRAY
564 QMLKDIKKEKVLLRR
572 EKVLLRRKSELPQDV
583 PQDVYTIKALEAHKR
73 PTQLSKIKYSGGPQI
82 SGGPQIVKKERRQSS

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment

Protein Sequence

10 MPYKLKKEKE 20 PPKVAKCTAK 30 PSSSGKDGGG 40 ENTEEAQPQP 50 QPQPQPQAQS 60 QPPSSNKRPS 70 NSTPPPTQLS 80 KIKYSGGPQI 90 VKKERRQSSS 100 RFNLSKNREL 110 QKLPALKDSP 120 TQEREELFIQ 130 KLRQCCVLFD 140 FVSDPLSDLK 150 FKEVKRAGLN 160 EMVEYITHSR 170 DVVTEAIYPE 180 AVTMFSVNLF 190 RTLPPSSNPT 200 GAEFDPEEDE 210 PTLEAAWPHL 220 QLVYEFFLRF 230 LESPDFQPNI 240 AKKYIDQKFV 250 LALLDLFDSE 260 DPRERDFLKT 270 ILHRIYGKFL 280 GLRAYIRRQI 290 NHIFYRFIYE 300 TEHHNGIAEL 310 LEILGSIING 320 FALPLKEEHK 330 MFLIRVLLPL 340 HKVKSLSVYH 350 PQLAYCVVQF 360 LEKESSLTEP 370 VIVGLLKFWP 380 KTHSPKEVMF 390 LNELEEILDV 400 IEPSEFSKVM 410 EPLFRQLAKC 420 VSSPHFQVAE 430 RALYYWNNEY 440 IMSLISDNAA 450 RVLPIMFPAL 460 YRNSKSHWNK 470 TIHGLIYNAL 480 KLFMEMNQKL 490 FDDCTQQYKA 500 EKQKGRFRMK 510 EREEMWQKIE 520 ELARLNPQYP 530 MFRAPPPLPP 540 VYSMETETPT 550 AEDIQLLKRT 560 VETEAVQMLK 570 DIKKEKVLLR 580 RKSELPQDVY 590 TIKALEAHKR 600 AEEFLTASQE AL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000159 protein phosphatase type 2A complex
Molecular Function GO:0072542 protein phosphatase activator activity
Molecular Function GO:0019888 protein phosphatase regulator activity
Biological Process GO:0051177 meiotic sister chromatid cohesion
Biological Process GO:0007399 nervous system development
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.