Search Results

Overview

Uniprot IDQ14739
Protein NameDelta(14)-sterol reductase LBR
Gene NameLBR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
147 ERNDAPHKNTQEKFS
152 PHKNTQEKFSLSQES
176 RPRREEVKLKEIDSK
186 EIDSKEEKYVAKELA
5 ***MPSRKFADGEVV
508 FRGANSQKNAFRKNP
524 DPKLAHLKTIHTSTG
594 DEYHCKKKYGVAWEK

Function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963)

Protein Sequence

10 MPSRKFADGE 20 VVRGRWPGSS 30 LYYEVEILSH 40 DSTSQLYTVK 50 YKDGTELELK 60 ENDIKPLTSF 70 RQRKGGSTSS 80 SPSRRRGSRS 90 RSRSRSPGRP 100 PKSARRSASA 110 SHQADIKEAR 120 REVEVKLTPL 130 ILKPFGNSIS 140 RYNGEPEHIE 150 RNDAPHKNTQ 160 EKFSLSQESS 170 YIATQYSLRP 180 RREEVKLKEI 190 DSKEEKYVAK 200 ELAVRTFEVT 210 PIRAKDLEFG 220 GVPGVFLIMF 230 GLPVFLFLLL 240 LMCKQKDPSL 250 LNFPPPLPAL 260 YELWETRVFG 270 VYLLWFLIQV 280 LFYLLPIGKV 290 VEGTPLIDGR 300 RLKYRLNGFY 310 AFILTSAVIG 320 TSLFQGVEFH 330 YVYSHFLQFA 340 LAATVFCVVL 350 SVYLYMRSLK 360 APRNDLSPAS 370 SGNAVYDFFI 380 GRELNPRIGT 390 FDLKYFCELR 400 PGLIGWVVIN 410 LVMLLAEMKI 420 QDRAVPSLAM 430 ILVNSFQLLY 440 VVDALWNEEA 450 LLTTMDIIHD 460 GFGFMLAFGD 470 LVWVPFIYSF 480 QAFYLVSHPN 490 EVSWPMASLI 500 IVLKLCGYVI 510 FRGANSQKNA 520 FRKNPSDPKL 530 AHLKTIHTST 540 GKNLLVSGWW 550 GFVRHPNYLG 560 DLIMALAWSL 570 PCGFNHILPY 580 FYIIYFTMLL 590 VHREARDEYH 600 CKKKYGVAWE 610 KYCQRVPYRI FPYIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0005652 nuclear lamina
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140463 chromatin-protein adaptor activity
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0050613 Delta14-sterol reductase activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0005521 lamin binding
Molecular Function GO:0070402 NADPH binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033489 cholesterol biosynthetic process via desmosterol
Biological Process GO:0030223 neutrophil differentiation
Biological Process GO:0060816 random inactivation of X chromosome
Biological Process GO:0036197 zymosterol biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.