Search Results
Overview
| Uniprot ID | Q14749 |
|---|---|
| Protein Name | Glycine N-methyltransferase |
| Gene Name | GNMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 193 | TGCAPPGKNIYYKSD |
| 198 | PGKNIYYKSDLTKDV |
| 203 | YYKSDLTKDVTTSVL |
Function
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine
Protein Sequence
10
MVDSVYRTRS
20
LGVAAEGLPD
30
QYADGEAARV
40
WQLYIGDTRS
50
RTAEYKAWLL
60
GLLRQHGCQR
70
VLDVACGTGV
80
DSIMLVEEGF
90
SVTSVDASDK
100
MLKYALKERW
110
NRRHEPAFDK
120
WVIEEANWMT
130
LDKDVPQSAE
140
GGFDAVICLG
150
NSFAHLPDCK
160
GDQSEHRLAL
170
KNIASMVRAG
180
GLLVIDHRNY
190
DHILSTGCAP
200
PGKNIYYKSD
210
LTKDVTTSVL
220
IVNNKAHMVT
230
LDYTVQVPGA
240
GQDGSPGLSK
250
FRLSYYPHCL
260
ASFTELLQAA
270
FGGKCQHSVL
280
GDFKPYKPGQ
290
TYIPCYFIHV
LKRTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005542 | folic acid binding |
| Molecular Function | GO:0016594 | glycine binding |
| Molecular Function | GO:0017174 | glycine N-methyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:1904047 | S-adenosyl-L-methionine binding |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0006111 | regulation of gluconeogenesis |
| Biological Process | GO:0046498 | S-adenosylhomocysteine metabolic process |
| Biological Process | GO:0046500 | S-adenosylmethionine metabolic process |
| Biological Process | GO:1901052 | sarcosine metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.