Search Results

Overview

Uniprot IDQ14764
Protein NameMajor vault protein
Gene NameMVP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
299 GKNQLGQKRVVKGEK
692 RGRLERQKILDQSEA
701 LDQSEAEKARKELLE
745 EGSVLQAKLKAQALA
747 SVLQAKLKAQALAIE
796 EVEVKKFKQMTEAIG

Function

Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (PubMed:40691181). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (PubMed:40691181). Vaults may play a role in nucleo-cytoplasmic transport (PubMed:15133037). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (PubMed:16418217). Down-regulates SRC activity and signaling through MAP kinases (PubMed:16441665)

Protein Sequence

10 MATEEFIIRI 20 PPYHYIHVLD 30 QNSNVSRVEV 40 GPKTYIRQDN 50 ERVLFAPMRM 60 VTVPPRHYCT 70 VANPVSRDAQ 80 GLVLFDVTGQ 90 VRLRHADLEI 100 RLAQDPFPLY 110 PGEVLEKDIT 120 PLQVVLPNTA 130 LHLKALLDFE 140 DKDGDKVVAG 150 DEWLFEGPGT 160 YIPRKEVEVV 170 EIIQATIIRQ 180 NQALRLRARK 190 ECWDRDGKER 200 VTGEEWLVTT 210 VGAYLPAVFE 220 EVLDLVDAVI 230 LTEKTALHLR 240 ARRNFRDFRG 250 VSRRTGEEWL 260 VTVQDTEAHV 270 PDVHEEVLGV 280 VPITTLGPHN 290 YCVILDPVGP 300 DGKNQLGQKR 310 VVKGEKSFFL 320 QPGEQLEQGI 330 QDVYVLSEQQ 340 GLLLRALQPL 350 EEGEDEEKVS 360 HQAGDHWLIR 370 GPLEYVPSAK 380 VEVVEERQAI 390 PLDENEGIYV 400 QDVKTGKVRA 410 VIGSTYMLTQ 420 DEVLWEKELP 430 PGVEELLNKG 440 QDPLADRGEK 450 DTAKSLQPLA 460 PRNKTRVVSY 470 RVPHNAAVQV 480 YDYREKRARV 490 VFGPELVSLG 500 PEEQFTVLSL 510 SAGRPKRPHA 520 RRALCLLLGP 530 DFFTDVITIE 540 TADHARLQLQ 550 LAYNWHFEVN 560 DRKDPQETAK 570 LFSVPDFVGD 580 ACKAIASRVR 590 GAVASVTFDD 600 FHKNSARIIR 610 TAVFGFETSE 620 AKGPDGMALP 630 RPRDQAVFPQ 640 NGLVVSSVDV 650 QSVEPVDQRT 660 RDALQRSVQL 670 AIEITTNSQE 680 AAAKHEAQRL 690 EQEARGRLER 700 QKILDQSEAE 710 KARKELLELE 720 ALSMAVESTG 730 TAKAEAESRA 740 EAARIEGEGS 750 VLQAKLKAQA 760 LAIETEAELQ 770 RVQKVRELEL 780 VYARAQLELE 790 VSKAQQLAEV 800 EVKKFKQMTE 810 AIGPSTIRDL 820 AVAGPEMQVK 830 LLQSLGLKST 840 LITDGSTPIN 850 LFNTAFGLLG 860 MGPEGQPLGR 870 RVASGPSPGE 880 GISPQSAQAP 890 QAPGDNHVVP VLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0019903 protein phosphatase binding
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0038127 ERBB signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0051028 mRNA transport
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0072376 protein activation cascade
Biological Process GO:0015031 protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.