Search Results
Overview
| Uniprot ID | Q14781 |
|---|---|
| Protein Name | Chromobox protein homolog 2 |
| Gene Name | CBX2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | THPVPQKKAQILVAK |
| 157 | LVAKPELKDPIRKKR |
| 199 | DLGAPASKLPPPLSA |
| 283 | LKAQATNKCGLGLDL |
| 310 | PPGSKIPKAPSGGAV |
| 379 | ARHATATKGVPATNP |
| 427 | APPTPASKRDCVKGS |
| 432 | ASKRDCVKGSATPSG |
| 94 | SSCSRRSKLKEPDAP |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780)
Protein Sequence
10
MEELSSVGEQ
20
VFAAECILSK
30
RLRKGKLEYL
40
VKWRGWSSKH
50
NSWEPEENIL
60
DPRLLLAFQK
70
KEHEKEVQNR
80
KRGKRPRGRP
90
RKLTAMSSCS
100
RRSKLKEPDA
110
PSKSKSSSSS
120
SSSTSSSSSS
130
DEEDDSDLDA
140
KRGPRGRETH
150
PVPQKKAQIL
160
VAKPELKDPI
170
RKKRGRKPLP
180
PEQKATRRPV
190
SLAKVLKTAR
200
KDLGAPASKL
210
PPPLSAPVAG
220
LAALKAHAKE
230
ACGGPSAMAT
240
PENLASLMKG
250
MASSPGRGGI
260
SWQSSIVHYM
270
NRMTQSQAQA
280
ASRLALKAQA
290
TNKCGLGLDL
300
KVRTQKGELG
310
MSPPGSKIPK
320
APSGGAVEQK
330
VGNTGGPPHT
340
HGASRVPAGC
350
PGPQPAPTQE
360
LSLQVLDLQS
370
VKNGMPGVGL
380
LARHATATKG
390
VPATNPAPGK
400
GTGSGLIGAS
410
GATMPTDTSK
420
SEKLASRAVA
430
PPTPASKRDC
440
VKGSATPSGQ
450
ESRTAPGEAR
460
KAATLPEMSA
470
GEESSSSDSD
480
PDSASPPSTG
490
QNPSVSVQTS
500
QDWKPTRSLI
510
EHVFVTDVTA
520
NLITVTVKES
530
PTSVGFFNLR
HY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031519 | PcG protein complex |
| Cellular Component | GO:0035102 | PRC1 complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0062072 | histone H3K9me2/3 reader activity |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0045137 | development of primary sexual characteristics |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Reference
PMID: N/A