Search Results
Overview
| Uniprot ID | Q14807 |
|---|---|
| Protein Name | Kinesin-like protein KIF22 |
| Gene Name | KIF22 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 287 | DNRRTGNKGLRLKES |
| 292 | GNKGLRLKESGAINT |
| 32 | AGRCRLSKIGATRRP |
| 465 | APLLSTPKRERMVLM |
| 527 | VTGAKPLKKAVVMPL |
| 559 | KNKGRKRKLESLDAL |
Function
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205)
Protein Sequence
10
MAAGGSTQQR
20
RREMAAASAA
30
AISGAGRCRL
40
SKIGATRRPP
50
PARVRVAVRL
60
RPFVDGTAGA
70
SDPPCVRGMD
80
SCSLEIANWR
90
NHQETLKYQF
100
DAFYGERSTQ
110
QDIYAGSVQP
120
ILRHLLEGQN
130
ASVLAYGPTG
140
AGKTHTMLGS
150
PEQPGVIPRA
160
LMDLLQLTRE
170
EGAEGRPWAL
180
SVTMSYLEIY
190
QEKVLDLLDP
200
ASGDLVIRED
210
CRGNILIPGL
220
SQKPISSFAD
230
FERHFLPASR
240
NRTVGATRLN
250
QRSSRSHAVL
260
LVKVDQRERL
270
APFRQREGKL
280
YLIDLAGSED
290
NRRTGNKGLR
300
LKESGAINTS
310
LFVLGKVVDA
320
LNQGLPRVPY
330
RDSKLTRLLQ
340
DSLGGSAHSI
350
LIANIAPERR
360
FYLDTVSALN
370
FAARSKEVIN
380
RPFTNESLQP
390
HALGPVKLSQ
400
KELLGPPEAK
410
RARGPEEEEI
420
GSPEPMAAPA
430
SASQKLSPLQ
440
KLSSMDPAML
450
ERLLSLDRLL
460
ASQGSQGAPL
470
LSTPKRERMV
480
LMKTVEEKDL
490
EIERLKTKQK
500
ELEAKMLAQK
510
AEEKENHCPT
520
MLRPLSHRTV
530
TGAKPLKKAV
540
VMPLQLIQEQ
550
AASPNAEIHI
560
LKNKGRKRKL
570
ESLDALEPEE
580
KAEDCWELQI
590
SPELLAHGRQ
600
KILDLLNEGS
610
ARDLRSLQRI
620
GPKKAQLIVG
630
WRELHGPFSQ
640
VEDLERVEGI
650
TGKQMESFLK
660
ANILGLAAGQ
RCGAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0051310 | metaphase chromosome alignment |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0007062 | sister chromatid cohesion |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.