Search Results

Overview

Uniprot ID	Q14814
Protein Name	Myocyte-specific enhancer factor 2D
Gene Name	MEF2D
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
245	ANGNSLNKVIPAKSP
511	EAEGSAVKRMRLDTW

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)

Protein Sequence

10 MGRKKIQIQR 20 ITDERNRQVT 30 FTKRKFGLMK 40 KAYELSVLCD 50 CEIALIIFNH 60 SNKLFQYAST 70 DMDKVLLKYT 80 EYNEPHESRT 90 NADIIETLRK 100 KGFNGCDSPE 110 PDGEDSLEQS 120 PLLEDKYRRA 130 SEELDGLFRR 140 YGSTVPAPNF 150 AMPVTVPVSN 160 QSSLQFSNPS 170 GSLVTPSLVT 180 SSLTDPRLLS 190 PQQPALQRNS 200 VSPGLPQRPA 210 SAGAMLGGDL 220 NSANGACPSP 230 VGNGYVSARA 240 SPGLLPVANG 250 NSLNKVIPAK 260 SPPPPTHSTQ 270 LGAPSRKPDL 280 RVITSQAGKG 290 LMHHLTEDHL 300 DLNNAQRLGV 310 SQSTHSLTTP 320 VVSVATPSLL 330 SQGLPFSSMP 340 TAYNTDYQLT 350 SAELSSLPAF 360 SSPGGLSLGN 370 VTAWQQPQQP 380 QQPQQPQPPQ 390 QQPPQPQQPQ 400 PQQPQQPQQP 410 PQQQSHLVPV 420 SLSNLIPGSP 430 LPHVGAALTV 440 TTHPHISIKS 450 EPVSPSRERS 460 PAPPPPAVFP 470 AARPEPGDGL 480 SSPAGGSYET 490 GDRDDGRGDF 500 GPTLGLLRPA 510 PEPEAEGSAV 520 KRMRLDTWTL K

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0046983	protein dimerization activity
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Biological Process	GO:0007512	adult heart development
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.