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Overview

Uniprot ID	Q14833
Protein Name	Metabotropic glutamate receptor 4
Gene Name	GRM4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
241	GVEAFIQKSREDGGV

Function

G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity

Protein Sequence

10 MPGKRGLGWW 20 WARLPLCLLL 30 SLYGPWMPSS 40 LGKPKGHPHM 50 NSIRIDGDIT 60 LGGLFPVHGR 70 GSEGKPCGEL 80 KKEKGIHRLE 90 AMLFALDRIN 100 NDPDLLPNIT 110 LGARILDTCS 120 RDTHALEQSL 130 TFVQALIEKD 140 GTEVRCGSGG 150 PPIITKPERV 160 VGVIGASGSS 170 VSIMVANILR 180 LFKIPQISYA 190 STAPDLSDNS 200 RYDFFSRVVP 210 SDTYQAQAMV 220 DIVRALKWNY 230 VSTVASEGSY 240 GESGVEAFIQ 250 KSREDGGVCI 260 AQSVKIPREP 270 KAGEFDKIIR 280 RLLETSNARA 290 VIIFANEDDI 300 RRVLEAARRA 310 NQTGHFFWMG 320 SDSWGSKIAP 330 VLHLEEVAEG 340 AVTILPKRMS 350 VRGFDRYFSS 360 RTLDNNRRNI 370 WFAEFWEDNF 380 HCKLSRHALK 390 KGSHVKKCTN 400 RERIGQDSAY 410 EQEGKVQFVI 420 DAVYAMGHAL 430 HAMHRDLCPG 440 RVGLCPRMDP 450 VDGTQLLKYI 460 RNVNFSGIAG 470 NPVTFNENGD 480 APGRYDIYQY 490 QLRNDSAEYK 500 VIGSWTDHLH 510 LRIERMHWPG 520 SGQQLPRSIC 530 SLPCQPGERK 540 KTVKGMPCCW 550 HCEPCTGYQY 560 QVDRYTCKTC 570 PYDMRPTENR 580 TGCRPIPIIK 590 LEWGSPWAVL 600 PLFLAVVGIA 610 ATLFVVITFV 620 RYNDTPIVKA 630 SGRELSYVLL 640 AGIFLCYATT 650 FLMIAEPDLG 660 TCSLRRIFLG 670 LGMSISYAAL 680 LTKTNRIYRI 690 FEQGKRSVSA 700 PRFISPASQL 710 AITFSLISLQ 720 LLGICVWFVV 730 DPSHSVVDFQ 740 DQRTLDPRFA 750 RGVLKCDISD 760 LSLICLLGYS 770 MLLMVTCTVY 780 AIKTRGVPET 790 FNEAKPIGFT 800 MYTTCIVWLA 810 FIPIFFGTSQ 820 SADKLYIQTT 830 TLTVSVSLSA 840 SVSLGMLYMP 850 KVYIILFHPE 860 QNVPKRKRSL 870 KAVVTAATMS 880 NKFTQKGNFR 890 PNGEAKSELC 900 ENLEAPALAT 910 KQTYVTYTNH AI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse
Molecular Function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
Molecular Function	GO:0004930	G protein-coupled receptor activity
Molecular Function	GO:0008066	glutamate receptor activity
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
Biological Process	GO:0007268	chemical synaptic transmission
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway
Biological Process	GO:0007269	neurotransmitter secretion
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0043523	regulation of neuron apoptotic process
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.