Search Results

Overview

Uniprot IDQ14839
Protein NameATP-dependent chromatin remodeler CHD4
Gene NameCHD4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1051 ALIRASGKLLLLQKM
1206 VRPGLGSKTGSMSKQ
1341 GKGKRIRKQVNYNDG
1396 RKGLRNDKDKPLPPL
266 KAKTKEGKGPNARRK
275 PNARRKPKGSPRVPD
295 PKKVAPLKIKLGGFG
297 KVAPLKIKLGGFGSK
304 KLGGFGSKRKRSSSE
634 ILNHSVDKKGHVHYL
687 GEEGRPGKKLKKVKL
696 LKKVKLRKLERPPET
832 DNAIRGGKKASRMKK
833 NAIRGGKKASRMKKE

Function

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity)

Protein Sequence

10 MASGLGSPSP 20 CSAGSEEEDM 30 DALLNNSLPP 40 PHPENEEDPE 50 EDLSETETPK 60 LKKKKKPKKP 70 RDPKIPKSKR 80 QKKERMLLCR 90 QLGDSSGEGP 100 EFVEEEEEVA 110 LRSDSEGSDY 120 TPGKKKKKKL 130 GPKKEKKSKS 140 KRKEEEEEED 150 DDDDSKEPKS 160 SAQLLEDWGM 170 EDIDHVFSEE 180 DYRTLTNYKA 190 FSQFVRPLIA 200 AKNPKIAVSK 210 MMMVLGAKWR 220 EFSTNNPFKG 230 SSGASVAAAA 240 AAAVAVVESM 250 VTATEVAPPP 260 PPVEVPIRKA 270 KTKEGKGPNA 280 RRKPKGSPRV 290 PDAKKPKPKK 300 VAPLKIKLGG 310 FGSKRKRSSS 320 EDDDLDVESD 330 FDDASINSYS 340 VSDGSTSRSS 350 RSRKKLRTTK 360 KKKKGEEEVT 370 AVDGYETDHQ 380 DYCEVCQQGG 390 EIILCDTCPR 400 AYHMVCLDPD 410 MEKAPEGKWS 420 CPHCEKEGIQ 430 WEAKEDNSEG 440 EEILEEVGGD 450 LEEEDDHHME 460 FCRVCKDGGE 470 LLCCDTCPSS 480 YHIHCLNPPL 490 PEIPNGEWLC 500 PRCTCPALKG 510 KVQKILIWKW 520 GQPPSPTPVP 530 RPPDADPNTP 540 SPKPLEGRPE 550 RQFFVKWQGM 560 SYWHCSWVSE 570 LQLELHCQVM 580 FRNYQRKNDM 590 DEPPSGDFGG 600 DEEKSRKRKN 610 KDPKFAEMEE 620 RFYRYGIKPE 630 WMMIHRILNH 640 SVDKKGHVHY 650 LIKWRDLPYD 660 QASWESEDVE 670 IQDYDLFKQS 680 YWNHRELMRG 690 EEGRPGKKLK 700 KVKLRKLERP 710 PETPTVDPTV 720 KYERQPEYLD 730 ATGGTLHPYQ 740 MEGLNWLRFS 750 WAQGTDTILA 760 DEMGLGKTVQ 770 TAVFLYSLYK 780 EGHSKGPFLV 790 SAPLSTIINW 800 EREFEMWAPD 810 MYVVTYVGDK 820 DSRAIIRENE 830 FSFEDNAIRG 840 GKKASRMKKE 850 ASVKFHVLLT 860 SYELITIDMA 870 ILGSIDWACL 880 IVDEAHRLKN 890 NQSKFFRVLN 900 GYSLQHKLLL 910 TGTPLQNNLE 920 ELFHLLNFLT 930 PERFHNLEGF 940 LEEFADIAKE 950 DQIKKLHDML 960 GPHMLRRLKA 970 DVFKNMPSKT 980 ELIVRVELSP 990 MQKKYYKYIL 1000 TRNFEALNAR 1010 GGGNQVSLLN 1020 VVMDLKKCCN 1030 HPYLFPVAAM 1040 EAPKMPNGMY 1050 DGSALIRASG 1060 KLLLLQKMLK 1070 NLKEGGHRVL 1080 IFSQMTKMLD 1090 LLEDFLEHEG 1100 YKYERIDGGI 1110 TGNMRQEAID 1120 RFNAPGAQQF 1130 CFLLSTRAGG 1140 LGINLATADT 1150 VIIYDSDWNP 1160 HNDIQAFSRA 1170 HRIGQNKKVM 1180 IYRFVTRASV 1190 EERITQVAKK 1200 KMMLTHLVVR 1210 PGLGSKTGSM 1220 SKQELDDILK 1230 FGTEELFKDE 1240 ATDGGGDNKE 1250 GEDSSVIHYD 1260 DKAIERLLDR 1270 NQDETEDTEL 1280 QGMNEYLSSF 1290 KVAQYVVREE 1300 EMGEEEEVER 1310 EIIKQEESVD 1320 PDYWEKLLRH 1330 HYEQQQEDLA 1340 RNLGKGKRIR 1350 KQVNYNDGSQ 1360 EDRDWQDDQS 1370 DNQSDYSVAS 1380 EEGDEDFDER 1390 SEAPRRPSRK 1400 GLRNDKDKPL 1410 PPLLARVGGN 1420 IEVLGFNARQ 1430 RKAFLNAIMR 1440 YGMPPQDAFT 1450 TQWLVRDLRG 1460 KSEKEFKAYV 1470 SLFMRHLCEP 1480 GADGAETFAD 1490 GVPREGLSRQ 1500 HVLTRIGVMS 1510 LIRKKVQEFE 1520 HVNGRWSMPE 1530 LAEVEENKKM 1540 SQPGSPSPKT 1550 PTPSTPGDTQ 1560 PNTPAPVPPA 1570 EDGIKIEENS 1580 LKEEESIEGE 1590 KEVKSTAPET 1600 AIECTQAPAP 1610 ASEDEKVVVE 1620 PPEGEEKVEK 1630 AEVKERTEEP 1640 METEPKGAAD 1650 VEKVEEKSAI 1660 DLTPIVVEDK 1670 EEKKEEEEKK 1680 EVMLQNGETP 1690 KDLNDEKQKK 1700 NIKQRFMFNI 1710 ADGGFTELHS 1720 LWQNEERAAT 1730 VTKKTYEIWH 1740 RRHDYWLLAG 1750 IINHGYARWQ 1760 DIQNDPRYAI 1770 LNEPFKGEMN 1780 RGNFLEIKNK 1790 FLARRFKLLE 1800 QALVIEEQLR 1810 RAAYLNMSED 1820 PSHPSMALNT 1830 RFAEVECLAE 1840 SHQHLSKESM 1850 AGNKPANAVL 1860 HKVLKQLEEL 1870 LSDMKADVTR 1880 LPATIARIPP 1890 VAVRLQMSER 1900 NILSRLANRA 1910 PEPTPQQVAQ QQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0150048 cerebellar granule cell to Purkinje cell synapse
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Cellular Component GO:0090734 site of DNA damage
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0042659 regulation of cell fate specification
Biological Process GO:2000736 regulation of stem cell differentiation
Biological Process GO:0051963 regulation of synapse assembly
Biological Process GO:0072553 terminal button organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.