Search Results

Overview

Uniprot IDQ14847
Protein NameLIM and SH3 domain protein 1
Gene NameLASP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 PELQRIKKTQDQISN
121 QDQISNIKYHEEFEK
128 KYHEEFEKSRMGPSG
17 KIVYPTEKVNCLDKF
205 SAPGGGGKRYRAVYD
23 EKVNCLDKFWHKACF
27 CLDKFWHKACFHCET
42 CKMTLNMKNYKGYEK
45 TLNMKNYKGYEKKPY
49 KNYKGYEKKPYCNAH
50 NYKGYEKKPYCNAHY
59 YCNAHYPKQSFTMVA
75 TPENLRLKQQSELQS
87 LQSQVRYKEEFEKNK
92 RYKEEFEKNKGKGFS
96 EFEKNKGKGFSVVAD

Function

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)

Protein Sequence

10 MNPNCARCGK 20 IVYPTEKVNC 30 LDKFWHKACF 40 HCETCKMTLN 50 MKNYKGYEKK 60 PYCNAHYPKQ 70 SFTMVADTPE 80 NLRLKQQSEL 90 QSQVRYKEEF 100 EKNKGKGFSV 110 VADTPELQRI 120 KKTQDQISNI 130 KYHEEFEKSR 140 MGPSGGEGME 150 PERRDSQDGS 160 SYRRPLEQQQ 170 PHHIPTSAPV 180 YQQPQQQPVA 190 QSYGGYKEPA 200 APVSIQRSAP 210 GGGGKRYRAV 220 YDYSAADEDE 230 VSFQDGDTIV 240 NVQQIDDGWM 250 YGTVERTGDT 260 GMLPANYVEA I

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0015075 monoatomic ion transmembrane transporter activity
Biological Process GO:0006811 monoatomic ion transport

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.