Search Results

Overview

Uniprot IDQ14865
Protein NameAT-rich interactive domain-containing protein 5B
Gene NameARID5B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1027 DLVIAGKKARAVSPL
269 RDSFSGVKDSNNNSD
310 VSNEEKPKVAIGEEC
561 ALVPGASKQPLTSPS
720 PPPLISKKKLIARDD
912 PTDLSLPKNPHKPTG

Function

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer

Protein Sequence

10 MEPNSLQWVG 20 SPCGLHGPYI 30 FYKAFQFHLE 40 GKPRILSLGD 50 FFFVRCTPKD 60 PICIAELQLL 70 WEERTSRQLL 80 SSSKLYFLPE 90 DTPQGRNSDH 100 GEDEVIAVSE 110 KVIVKLEDLV 120 KWVHSDFSKW 130 RCGFHAGPVK 140 TEALGRNGQK 150 EALLKYRQST 160 LNSGLNFKDV 170 LKEKADLGED 180 EEETNVIVLS 190 YPQYCRYRSM 200 LKRIQDKPSS 210 ILTDQFALAL 220 GGIAVVSRNP 230 QILYCRDTFD 240 HPTLIENESI 250 CDEFAPNLKG 260 RPRKKKPCPQ 270 RRDSFSGVKD 280 SNNNSDGKAV 290 AKVKCEARSA 300 LTKPKNNHNC 310 KKVSNEEKPK 320 VAIGEECRAD 330 EQAFLVALYK 340 YMKERKTPIE 350 RIPYLGFKQI 360 NLWTMFQAAQ 370 KLGGYETITA 380 RRQWKHIYDE 390 LGGNPGSTSA 400 ATCTRRHYER 410 LILPYERFIK 420 GEEDKPLPPI 430 KPRKQENSSQ 440 ENENKTKVSG 450 TKRIKHEIPK 460 SKKEKENAPK 470 PQDAAEVSSE 480 QEKEQETLIS 490 QKSIPEPLPA 500 ADMKKKIEGY 510 QEFSAKPLAS 520 RVDPEKDNET 530 DQGSNSEKVA 540 EEAGEKGPTP 550 PLPSAPLAPE 560 KDSALVPGAS 570 KQPLTSPSAL 580 VDSKQESKLC 590 CFTESPESEP 600 QEASFPSFPT 610 TQPPLANQNE 620 TEDDKLPAMA 630 DYIANCTVKV 640 DQLGSDDIHN 650 ALKQTPKVLV 660 VQSFDMFKDK 670 DLTGPMNENH 680 GLNYTPLLYS 690 RGNPGIMSPL 700 AKKKLLSQVS 710 GASLSSSYPY 720 GSPPPLISKK 730 KLIARDDLCS 740 SLSQTHHGQS 750 TDHMAVSRPS 760 VIQHVQSFRS 770 KPSEERKTIN 780 DIFKHEKLSR 790 SDPHRCSFSK 800 HHLNPLADSY 810 VLKQEIQEGK 820 DKLLEKRALP 830 HSHMPSFLAD 840 FYSSPHLHSL 850 YRHTEHHLHN 860 EQTSKYPSRD 870 MYRESENSSF 880 PSHRHQEKLH 890 VNYLTSLHLQ 900 DKKSAAAEAP 910 TDDQPTDLSL 920 PKNPHKPTGK 930 VLGLAHSTTG 940 PQESKGISQF 950 QVLGSQSRDC 960 HPKACRVSPM 970 TMSGPKKYPE 980 SLSRSGKPHH 990 VRLENFRKME 1000 GMVHPILHRK 1010 MSPQNIGAAR 1020 PIKRSLEDLD 1030 LVIAGKKARA 1040 VSPLDPSKEV 1050 SGKEKASEQE 1060 SEGSKAAHGG 1070 HSGGGSEGHK 1080 LPLSSPIFPG 1090 LYSGSLCNSG 1100 LNSRLPAGYS 1110 HSLQYLKNQT 1120 VLSPLMQPLA 1130 FHSLVMQRGI 1140 FTSPTNSQQL 1150 YRHLAAATPV 1160 GSSYGDLLHN 1170 SIYPLAAINP 1180 QAAFPSSQLS SVHPSTKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0001889 liver development
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0045815 transcription initiation-coupled chromatin remodeling
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0060612 adipose tissue development

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.