Search Results

Overview

Uniprot ID	Q14896
Protein Name	Myosin-binding protein C, cardiac-type
Gene Name	MYBPC3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
485	SEEGAQVKWLKDGVE

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role

Protein Sequence

10 MPEPGKKPVS 20 AFSKKPRSVE 30 VAAGSPAVFE 40 AETERAGVKV 50 RWQRGGSDIS 60 ASNKYGLATE 70 GTRHTLTVRE 80 VGPADQGSYA 90 VIAGSSKVKF 100 DLKVIEAEKA 110 EPMLAPAPAP 120 AEATGAPGEA 130 PAPAAELGES 140 APSPKGSSSA 150 ALNGPTPGAP 160 DDPIGLFVMR 170 PQDGEVTVGG 180 SITFSARVAG 190 ASLLKPPVVK 200 WFKGKWVDLS 210 SKVGQHLQLH 220 DSYDRASKVY 230 LFELHITDAQ 240 PAFTGSYRCE 250 VSTKDKFDCS 260 NFNLTVHEAM 270 GTGDLDLLSA 280 FRRTSLAGGG 290 RRISDSHEDT 300 GILDFSSLLK 310 KRDSFRTPRD 320 SKLEAPAEED 330 VWEILRQAPP 340 SEYERIAFQY 350 GVTDLRGMLK 360 RLKGMRRDEK 370 KSTAFQKKLE 380 PAYQVSKGHK 390 IRLTVELADH 400 DAEVKWLKNG 410 QEIQMSGSKY 420 IFESIGAKRT 430 LTISQCSLAD 440 DAAYQCVVGG 450 EKCSTELFVK 460 EPPVLITRPL 470 EDQLVMVGQR 480 VEFECEVSEE 490 GAQVKWLKDG 500 VELTREETFK 510 YRFKKDGQRH 520 HLIINEAMLE 530 DAGHYALCTS 540 GGQALAELIV 550 QEKKLEVYQS 560 IADLMVGAKD 570 QAVFKCEVSD 580 ENVRGVWLKN 590 GKELVPDSRI 600 KVSHIGRVHK 610 LTIDDVTPAD 620 EADYSFVPEG 630 FACNLSAKLH 640 FMEVKIDFVP 650 RQEPPKIHLD 660 CPGRIPDTIV 670 VVAGNKLRLD 680 VPISGDPAPT 690 VIWQKAITQG 700 NKAPARPAPD 710 APEDTGDSDE 720 WVFDKKLLCE 730 TEGRVRVETT 740 KDRSIFTVEG 750 AEKEDEGVYT 760 VTVKNPVGED 770 QVNLTVKVID 780 VPDAPAAPKI 790 SNVGEDSCTV 800 QWEPPAYDGG 810 QPILGYILER 820 KKKKSYRWMR 830 LNFDLIQELS 840 HEARRMIEGV 850 VYEMRVYAVN 860 AIGMSRPSPA 870 SQPFMPIGPP 880 SEPTHLAVED 890 VSDTTVSLKW 900 RPPERVGAGG 910 LDGYSVEYCP 920 EGCSEWVAAL 930 QGLTEHTSIL 940 VKDLPTGARL 950 LFRVRAHNMA 960 GPGAPVTTTE 970 PVTVQEILQR 980 PRLQLPRHLR 990 QTIQKKVGEP 1000 VNLLIPFQGK 1010 PRPQVTWTKE 1020 GQPLAGEEVS 1030 IRNSPTDTIL 1040 FIRAARRVHS 1050 GTYQVTVRIE 1060 NMEDKATLVL 1070 QVVDKPSPPQ 1080 DLRVTDAWGL 1090 NVALEWKPPQ 1100 DVGNTELWGY 1110 TVQKADKKTM 1120 EWFTVLEHYR 1130 RTHCVVPELI 1140 IGNGYYFRVF 1150 SQNMVGFSDR 1160 AATTKEPVFI 1170 PRPGITYEPP 1180 NYKALDFSEA 1190 PSFTQPLVNR 1200 SVIAGYTAML 1210 CCAVRGSPKP 1220 KISWFKNGLD 1230 LGEDARFRMF 1240 SKQGVLTLEI 1250 RKPCPFDGGI 1260 YVCRATNLQG 1270 EARCECRLEV RVPQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031672	A band
Cellular Component	GO:0014705	C zone
Cellular Component	GO:0097512	cardiac myofibril
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031430	M band
Cellular Component	GO:0030017	sarcomere
Cellular Component	GO:0005863	striated muscle myosin thick filament
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0001671	ATPase activator activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0017022	myosin binding
Molecular Function	GO:0032036	myosin heavy chain binding
Molecular Function	GO:0008307	structural constituent of muscle
Molecular Function	GO:0031432	titin binding
Biological Process	GO:0060048	cardiac muscle contraction
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0003007	heart morphogenesis
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction
Biological Process	GO:0032971	regulation of muscle filament sliding
Biological Process	GO:0006942	regulation of striated muscle contraction
Biological Process	GO:0045214	sarcomere organization
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.