Search Results

Overview

Uniprot IDQ14914
Protein NameProstaglandin reductase 1
Gene NamePTGR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 THSISDGKDLEKLLT
11 TKTWTLKKHFVGYPT
168 IAKLKGCKVVGAVGS
178 GAVGSDEKVAYLQKL
204 ESLEETLKKASPDGY
324 LKGDNLGKTIVKA**
5 ***MVRTKTWTLKKH
58 RVAAKRLKEGDTMMG
70 MMGQQVAKVVESKNV
75 VAKVVESKNVALPKG

Function

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)

Protein Sequence

10 MVRTKTWTLK 20 KHFVGYPTNS 30 DFELKTAELP 40 PLKNGEVLLE 50 ALFLTVDPYM 60 RVAAKRLKEG 70 DTMMGQQVAK 80 VVESKNVALP 90 KGTIVLASPG 100 WTTHSISDGK 110 DLEKLLTEWP 120 DTIPLSLALG 130 TVGMPGLTAY 140 FGLLEICGVK 150 GGETVMVNAA 160 AGAVGSVVGQ 170 IAKLKGCKVV 180 GAVGSDEKVA 190 YLQKLGFDVV 200 FNYKTVESLE 210 ETLKKASPDG 220 YDCYFDNVGG 230 EFSNTVIGQM 240 KKFGRIAICG 250 AISTYNRTGP 260 LPPGPPPEIV 270 IYQELRMEAF 280 VVYRWQGDAR 290 QKALKDLLKW 300 VLEGKIQYKE 310 YIIEGFENMP 320 AAFMGMLKGD NLGKTIVKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0036185 13-lipoxin reductase activity
Molecular Function GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity
Molecular Function GO:0035798 2-alkenal reductase (NADPH) activity
Molecular Function GO:0097257 leukotriene B4 12-hydroxy dehydrogenase activity
Biological Process GO:0036102 leukotriene B4 metabolic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:2001302 lipoxin A4 metabolic process
Biological Process GO:0006693 prostaglandin metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.