Search Results

Overview

Uniprot IDQ14919
Protein NameDr1-associated corepressor
Gene NameDRAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 DNHMDGDKGARRGRK
19 FPPARIKKIMQTDEE

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own

Protein Sequence

10 MPSKKKKYNA 20 RFPPARIKKI 30 MQTDEEIGKV 40 AAAVPVIISR 50 ALELFLESLL 60 KKACQVTQSR 70 NAKTMTTSHL 80 KQCIELEQQF 90 DFLKDLVASV 100 PDMQGDGEDN 110 HMDGDKGARR 120 GRKPGSGGRK 130 NGGMGTKSKD 140 KKLSGTDSEQ 150 EDESEDTDTD 160 GEEETSQPPP 170 QASHPSAHFQ 180 SPPTPFLPFA 190 STLPLPPAPP 200 GPSAPDEEDE EDYDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017054 negative cofactor 2 complex
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0001046 core promoter sequence-specific DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0016251 RNA polymerase II general transcription initiation factor activity
Molecular Function GO:0001091 RNA polymerase II general transcription initiation factor binding
Molecular Function GO:0017025 TBP-class protein binding
Biological Process GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.