Search Results

Overview

Uniprot IDQ14966
Protein NameZinc finger protein 638
Gene NameZNF638
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1298 DEKTVDKKNISEKKG
1345 MDAEKVEKMAAMKEK
1360 PAENTLFKAYPNKGV
1365 LFKAYPNKGVGQANK
1395 SSSKPSIKAVIVSSP
1410 KAKATVSKTENQKSF
1415 VSKTENQKSFPKSVP
1419 ENQKSFPKSVPRDQI
1435 AEKKLSAKEFGLLKP
1455 GLAESSSKFKPTQSS
1477 RISALQGKLSKLDYR
1480 ALQGKLSKLDYRDIT
1516 TLAEQNTKNPKSTTG
1570 GKRKETLKNVPFSEL
1818 KRAVDTKKTKLESLS
1820 AVDTKKTKLESLSQV
1860 TKRVRIGKTLPSEKA
371 VGSRGSKKNYQSQAD
395 VKASWLPKFSHADAQ
403 FSHADAQKMKRLPTP
642 HSIRCKSKNLEDDTL
658 ECKQVSDKAVSLQRK
751 VKICVPGKKKAQNKE
794 VTSTSAAKTGQAKAS
799 AAKTGQAKASVAKVN
804 QAKASVAKVNKSTGK
825 SVVTVAVKGNKASIK
828 TVAVKGNKASIKTAK
853 KTGNVKNKDSNKPVT
86 DPRLTKEKLDFHEAQ
943 LILSSHKKAYIEINR
95 DFHEAQQKKGKPHGS
96 FHEAQQKKGKPHGSR

Function

Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity)

Protein Sequence

10 MSRPRFNPRG 20 DFPLQRPRAP 30 NPSGMRPPGP 40 FMRPGSMGLP 50 RFYPAGRARG 60 IPHRFAGHES 70 YQNMGPQRMN 80 VQVTQHRTDP 90 RLTKEKLDFH 100 EAQQKKGKPH 110 GSRWDDEPHI 120 SASVAVKQSS 130 VTQVTEQSPK 140 VQSRYTKESA 150 SSILASFGLS 160 NEDLEELSRY 170 PDEQLTPENM 180 PLILRDIRMR 190 KMGRRLPNLP 200 SQSRNKETLG 210 SEAVSSNVID 220 YGHASKYGYT 230 EDPLEVRIYD 240 PEIPTDEVEN 250 EFQSQQNISA 260 SVPNPNVICN 270 SMFPVEDVFR 280 QMDFPGESSN 290 NRSFFSVESG 300 TKMSGLHISG 310 GQSVLEPIKS 320 VNQSINQTVS 330 QTMSQSLIPP 340 SMNQQPFSSE 350 LISSVSQQER 360 IPHEPVINSS 370 NVHVGSRGSK 380 KNYQSQADIP 390 IRSPFGIVKA 400 SWLPKFSHAD 410 AQKMKRLPTP 420 SMMNDYYAAS 430 PRIFPHLCSL 440 CNVECSHLKD 450 WIQHQNTSTH 460 IESCRQLRQQ 470 YPDWNPEILP 480 SRRNEGNRKE 490 NETPRRRSHS 500 PSPRRSRRSS 510 SSHRFRRSRS 520 PMHYMYRPRS 530 RSPRICHRFI 540 SRYRSRSRSR 550 SPYRIRNPFR 560 GSPKCFRSVS 570 PERMSRRSVR 580 SSDRKKALED 590 VVQRSGHGTE 600 FNKQKHLEAA 610 DKGHSPAQKP 620 KTSSGTKPSV 630 KPTSATKSDS 640 NLGGHSIRCK 650 SKNLEDDTLS 660 ECKQVSDKAV 670 SLQRKLRKEQ 680 SLHYGSVLLI 690 TELPEDGCTE 700 EDVRKLFQPF 710 GKVNDVLIVP 720 YRKEAYLEME 730 FKEAITAIMK 740 YIETTPLTIK 750 GKSVKICVPG 760 KKKAQNKEVK 770 KKTLESKKVS 780 ASTLKRDADA 790 SKAVEIVTST 800 SAAKTGQAKA 810 SVAKVNKSTG 820 KSASSVKSVV 830 TVAVKGNKAS 840 IKTAKSGGKK 850 SLEAKKTGNV 860 KNKDSNKPVT 870 IPENSEIKTS 880 IEVKATENCA 890 KEAISDAALE 900 ATENEPLNKE 910 TEEMCVMLVS 920 NLPNKGYSVE 930 EVYDLAKPFG 940 GLKDILILSS 950 HKKAYIEINR 960 KAAESMVKFY 970 TCFPVLMDGN 980 QLSISMAPEN 990 MNIKDEEAIF 1000 ITLVKENDPE 1010 ANIDTIYDRF 1020 VHLDNLPEDG 1030 LQCVLCVGLQ 1040 FGKVDHHVFI 1050 SNRNKAILQL 1060 DSPESAQSMY 1070 SFLKQNPQNI 1080 GDHMLTCSLS 1090 PKIDLPEVQI 1100 EHDPELEKES 1110 PGLKNSPIDE 1120 SEVQTATDSP 1130 SVKPNELEEE 1140 STPSIQTETL 1150 VQQEEPCEEE 1160 AEKATCDSDF 1170 AVETLELETQ 1180 GEEVKEEIPL 1190 VASASVSIEQ 1200 FTENAEECAL 1210 NQQMFNSDLE 1220 KKGAEIINPK 1230 TALLPSDSVF 1240 AEERNLKGIL 1250 EESPSEAEDF 1260 ISGITQTMVE 1270 AVAEVEKNET 1280 VSEILPSTCI 1290 VTLVPGIPTG 1300 DEKTVDKKNI 1310 SEKKGNMDEK 1320 EEKEFNTKET 1330 RMDLQIGTEK 1340 AEKNEGRMDA 1350 EKVEKMAAMK 1360 EKPAENTLFK 1370 AYPNKGVGQA 1380 NKPDETSKTS 1390 ILAVSDVSSS 1400 KPSIKAVIVS 1410 SPKAKATVSK 1420 TENQKSFPKS 1430 VPRDQINAEK 1440 KLSAKEFGLL 1450 KPTSARSGLA 1460 ESSSKFKPTQ 1470 SSLTRGGSGR 1480 ISALQGKLSK 1490 LDYRDITKQS 1500 QETEARPSIM 1510 KRDDSNNKTL 1520 AEQNTKNPKS 1530 TTGRSSKSKE 1540 EPLFPFNLDE 1550 FVTVDEVIEE 1560 VNPSQAKQNP 1570 LKGKRKETLK 1580 NVPFSELNLK 1590 KKKGKTSTPR 1600 GVEGELSFVT 1610 LDEIGEEEDA 1620 AAHLAQALVT 1630 VDEVIDEEEL 1640 NMEEMVKNSN 1650 SLFTLDELID 1660 QDDCISHSEP 1670 KDVTVLSVAE 1680 EQDLLKQERL 1690 VTVDEIGEVE 1700 ELPLNESADI 1710 TFATLNTKGN 1720 EGDTVRDSIG 1730 FISSQVPEDP 1740 STLVTVDEIQ 1750 DDSSDLHLVT 1760 LDEVTEEDED 1770 SLADFNNLKE 1780 ELNFVTVDEV 1790 GEEEDGDNDL 1800 KVELAQSKND 1810 HPTDKKGNRK 1820 KRAVDTKKTK 1830 LESLSQVGPV 1840 NENVMEEDLK 1850 TMIERHLTAK 1860 TPTKRVRIGK 1870 TLPSEKAVVT 1880 EPAKGEEAFQ 1890 MSEVDEESGL 1900 KDSEPERKRK 1910 KTEDSSSGKS 1920 VASDVPEELD 1930 FLVPKAGFFC 1940 PICSLFYSGE 1950 KAMTNHCKST 1960 RHKQNTEKFM 1970 AKQRKEKEQN EAEERSSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043484 regulation of RNA splicing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.