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Overview

Uniprot IDQ14990
Protein NameOuter dense fiber protein 1
Gene NameODF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 IRAIEDEKRELAKLR
107 DEKRELAKLRRTTNR
144 DQVKVRVKDGKVCVS
147 KVRVKDGKVCVSAER
16 DSVRRDIKKVDRELR
164 RYDCLGSKKYSYMNI
165 YDCLGSKKYSYMNIC
17 SVRRDIKKVDRELRQ
184 LPPCVDEKDVTYSYG
79 PCCLCDYKLYCLRPS

Function

Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail

Protein Sequence

10 MAALSCLLDS 20 VRRDIKKVDR 30 ELRQLRCIDE 40 FSTRCLCDLY 50 MHPYCCCDLH 60 PYPYCLCYSK 70 RSRSCGLCDL 80 YPCCLCDYKL 90 YCLRPSLRSL 100 ERKAIRAIED 110 EKRELAKLRR 120 TTNRILASSC 130 CSSNILGSVN 140 VCGFEPDQVK 150 VRVKDGKVCV 160 SAERENRYDC 170 LGSKKYSYMN 180 ICKEFSLPPC 190 VDEKDVTYSY 200 GLGSCVKIES 210 PCYPCTSPCS 220 PCSPCSPCNP 230 CSPCNPCSPY 240 DPCNPCYPCG 250 SRFSCRKMIL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0002177 manchette
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001520 outer dense fiber
Cellular Component GO:0036126 sperm flagellum
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.